Rabbit anti-Rat Serotonin transporter Polyclonal Antibody | anti-SLC6A4 antibody

Anti-Serotonin transporter antibody

Cat. Num. AAA175633

• Reactivity: Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified.
• Synonyms: Serotonin transporter; Polyclonal Antibody; Anti-Serotonin transporter antibody; Sodium-dependent serotonin transporter; solute carrier family 6(neurotransmitter transporter; serotonin); member 5; 5 HTT antibody; 5 HTTLPR antibody; 5 hydroxytryptamine(serotonin) transporter antibody; 5 hydroxytryptamine transporter antibody; 5HT transporter antibody; 5HTT antibody; hSERT antibody; HTT antibody; Na+/Cl- dependent serotonin transporter antibody; OCD1 antibody; SC6A4_HUMAN antibody; Serotonin transporter 1 antibody; SERT antibody; SERT1 antibody; SLC6A4 antibody; Sodium dependent serotonin transporter antibody; Sodium-dependent serotonin transporter antibody; Solute carrier family 6(neurotransmitter transporter) member 4 antibody; member 4 antibody; Solute carrier family 6 member 4 antibody; anti-SLC6A4 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: No cross reactivity with other proteins
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 630

• Applicable Applications for anti-SLC6A4 antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin
• Application Notes: Western Blot: ; ; Concentration: 0.1-0.5 ug/ml; Tested Species: Rat; ; ; Immunohistochemistry (Paraffin-embedded section) ; ; Concentration: 0.5-1 ug/ml; Tested Species: Rat ; Antigen Retrieval: By Heat. ; ; ; Tested Species: In-house tested species with positive results. ; ; By Heat: Boiling the paraffin sections in 10 Mm citrate buffer, Ph 6.0 for 20 mins is required for the stainig of formalin/paraffin sections. ; ; Other applications have not been tested. ; ; Optimal dilutions should be determined by en users.
• Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of rat Serotonin transporter (7-24aa NSQKVLSECKDREDCQEN), different from the related mouse sequence by one amino acid.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-SLC6A4 antibody, MBS175633, IHC(P)IHC(P): Rat Brain Tissue )

Western Blot (WB)

(Anti-SLC6A4 antibody, MBS175633, Western blottingWB: Rat Brain Tissue Lysate )

Related Product Information for anti-SLC6A4 antibody

Description: Rabbit IgG polyclonal antibody for Sodium-dependent serotonin transporter(SLC6A4) detection. Tested with WB, IHC-P in Rat.
Background: SLC6A4(Solute carrier family 6, member 4), also known as SERT(serotonin transporter), is a monoamine transporter protein. The SLC6A4 gene spans 31 kb and contains 14 exons. This protein integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is the target of many antidepressant medications, including those of the SSRI class. It is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

NCBI and Uniprot Product Information

• NCBI GI #: 400629
• NCBI GeneID: 25553
• UniProt Accession #: P31652; P23976
• Molecular Weight: 70,172 Da
• NCBI Official Full Name: Sodium-dependent serotonin transporter
• NCBI Official Synonym Full Names: solute carrier family 6 (neurotransmitter transporter), member 4
• NCBI Official Symbol: Slc6a4
• NCBI Protein Information: sodium-dependent serotonin transporter; 5HTT; 5HT transporter; solute carrier family 6, member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; Solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter); solute carrier family 6 (neurotransmitter transporter serotonin) member 4 (5-hydroxytryptamine (serotonin) transporter)
• UniProt Protein Name: Sodium-dependent serotonin transporter
• UniProt Gene Name: Slc6a4
• UniProt Synonym Gene Names: 5HTT
• UniProt Entry Name: SC6A4_RAT

NCBI Description

binds serotonin; may play a role in regulation of motor activity [RGD, Feb 2006]

Uniprot Description

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.