Western Blot (WB)
((1ug/ml) staining of EBV immortalised Lymphoblastoid lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat Serotonin receptor 2C/HTR2C Polyclonal Antibody | anti-HTR2C antibody
Goat anti-Serotonin receptor 2C/HTR2C Antibody
Western Blot: Approx 50kDa band observed in lysates of Human immortalised Lymphoblastoids, T cell MOLT4 and monocytic cell line U937 (calculated MW of 51.8kDa according to NP_000859.1). Recommended concentration: 1-3ug/ml.
Western Blot (WB)
((1ug/ml) staining of EBV immortalised Lymphoblastoid lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((1ug/ml) staining of EBV immortalised Lymphoblastoid lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Description
5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: cytosol; integral to plasma membrane; plasma membrane
Molecular Function: 5-HT2 receptor activity; drug binding; serotonin binding; serotonin receptor activity
Biological Process: behavioral fear response; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; positive regulation of fat cell differentiation; positive regulation of phosphatidylinositol biosynthetic process; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; synaptic transmission
Research Articles on HTR2C
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Product Notes
The HTR2C htr2c (Catalog #AAA420937) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Serotonin receptor 2C/HTR2C Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's Serotonin receptor 2C/HTR2C can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 64000. Western Blot: Approx 50kDa band observed in lysates of Human immortalised Lymphoblastoids, T cell MOLT4 and monocytic cell line U937 (calculated MW of 51.8kDa according to NP_000859.1). Recommended concentration: 1-3ug/ml. Researchers should empirically determine the suitability of the HTR2C htr2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: QVENLELPVN. It is sometimes possible for the material contained within the vial of "Serotonin receptor 2C/HTR2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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