Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS1497174 at dilution 1:100)
Rabbit anti-Human Serine/threonine-protein kinase Nek2 Polyclonal Antibody | anti-NEK2 antibody
Rabbit anti-human Serine/threonine-protein kinase Nek2 polyclonal Antibody(NEK2)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS1497174 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney using MBS1497174 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
NEK2: a protein kinase of the NEK family. Accumulates throughout S phase and shows maximal levels in late G2. This expression pattern is highly reminiscent of that of A and B cyclins. Phosphorylation of Hec1 by Nek2 is essential for faithful chromosome segregation
Protein type: Nucleolus; EC 2.7.11.1; Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Other group; NEK family
Chromosomal Location of Human Ortholog: 1q32.3
Cellular Component: centrosome; condensed nuclear chromosome; cytoplasm; cytosol; kinetochore; microtubule; midbody; nucleolus; nucleus; protein complex; spindle pole
Molecular Function: ATP binding; metal ion binding; protein binding; protein kinase activity; protein phosphatase binding; protein serine/threonine kinase activity
Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; blastocyst development; cell division; centrosome separation; chromosome segregation; G2/M transition of mitotic cell cycle; meiotic cell cycle; mitosis; mitotic cell cycle; mitotic sister chromatid segregation; negative regulation of DNA binding; organelle organization and biogenesis; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of attachment of spindle microtubules to kinetochore; regulation of mitosis; regulation of mitotic centrosome separation; spindle assembly
Disease: Retinitis Pigmentosa 67
Research Articles on NEK2
Similar Products
Product Notes
The NEK2 nek2 (Catalog #AAA1497174) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human Serine/threonine-protein kinase Nek2 polyclonal Antibody(NEK2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Serine/threonine-protein kinase Nek2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC:1:20-1:200. Researchers should empirically determine the suitability of the NEK2 nek2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Serine/threonine-protein kinase Nek2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
