Mouse anti-Human SERF1A Polyclonal Antibody | anti-SERF1A antibody

SERF1A (Small EDRK-rich factor 1, 4F5, h4F5, SMA modifier 1, FAM2A, SERF1, SMAM1, SERF1B, FAM2B)

Cat. Num. AAA620002

• Gene Names: SERF1A; 4F5; H4F5; FAM2A; SERF1; SMAM1
• Reactivity: Human
• Applications: ELISA
• Purity: Serum; Serum
• Synonyms: SERF1A; Polyclonal Antibody; SERF1A (Small EDRK-rich factor 1; 4F5; h4F5; SMA modifier 1; FAM2A; SERF1; SMAM1; SERF1B; FAM2B); Anti -SERF1A (Small EDRK-rich factor 1; anti-SERF1A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human small EDRK-rich factor 1.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in 50% glycerol.

• Applicable Applications for anti-SERF1A antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Partial recombinant human Small EDRK-rich factor 1 (1-82) with a GST tag.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-SERF1A antibody

There are 2 named isoforms, a long and a short isoform, produced by alternative splicing. The long isoform is predominantly expressed in heart, brain and skeletal muscle. Both isoforms are also expressed throughout the central nervous system including the spinal cord. Deletions of the EDRK-rich factor 1 gene, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype.

Product Categories/Family for anti-SERF1A antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 196162708
• NCBI GeneID: 8293
• NCBI Accession #: NP_075257.1
• NCBI GenBank Nucleotide #: NM_022968.1
• UniProt Accession #: O75920; O75919; Q52LK5; B7ZKM2
• Molecular Weight: 12,349 Da
• NCBI Official Full Name: small EDRK-rich factor 1 isoform 2
• NCBI Official Synonym Full Names: small EDRK-rich factor 1A (telomeric)
• NCBI Official Symbol: SERF1A
• NCBI Official Synonym Symbols: 4F5; H4F5; FAM2A; SERF1; SMAM1
• NCBI Protein Information: small EDRK-rich factor 1; protein 4F5; SMA modifier 1; spinal muscular atrophy-related gene H4F5
• UniProt Protein Name: Small EDRK-rich factor 1
• UniProt Gene Name: SERF1A
• UniProt Synonym Gene Names: FAM2A; SERF1; SMAM1; h4F5
• UniProt Entry Name: SERF1_HUMAN

NCBI Description

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SERF1: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The duplication region includes both a telomeric and a centromeric copy of this gene. Deletions of this gene, the telomeric copy, often accompany deletions of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients, and so it is thought that this gene may be a modifier of the SMA phenotype. The function of this protein is not known; however, it bears low-level homology with the RNA-binding domain of matrin-cyclophilin, a protein which colocalizes with small nuclear ribonucleoproteins (snRNPs) and the SMN1 gene product. Alternatively spliced transcripts have been documented but it is unclear whether alternative splicing occurs for both the centromeric and telomeric copies of the gene. [provided by RefSeq, Jul 2008]

Chromosomal Location of Human Ortholog: 5q13

Biological Process: nervous system development