Western Blot (WB)
(Western Blot: Sample: Recombinant SLC, Rat.)
Rabbit anti-Rat Secondary Lymphoid Tissue Chemokine (SLC) Polyclonal Antibody | anti-SLC antibody
Polyclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC)
MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF-LALSLL SLVLVLCVPW TQGSDGGGQD CCLRYSQKKI PYNIVRGYRK QEPSLGCPIP AILFAPRKQS QPELCANPEE AWVQKLMRRL DQPPAPGKQN CRKNRGTSKS GKKGRGSKGC KGTEQTDSKR VS
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant SLC, Rat.)
Western Blot (WB)
(Western Blot: Sample: Recombinant SLC, Rat.)
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
Immunohistochemistry (IHC)
(DABstainingonIHC-P.Samples:RatTissue))
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]
Uniprot Description
CCL21: Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 9p13
Cellular Component: extracellular space; extracellular region
Molecular Function: chemokine receptor binding; chemokine activity; CCR7 chemokine receptor binding
Biological Process: positive regulation of filopodium formation; positive regulation of I-kappaB kinase/NF-kappaB cascade; formation of immunological synapse; positive regulation of chemotaxis; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of cell adhesion mediated by integrin; positive regulation of phosphoinositide 3-kinase activity; positive regulation of JNK cascade; positive regulation of receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of pseudopodium formation; cell-cell signaling; positive regulation of actin filament polymerization; positive regulation of protein kinase activity; release of sequestered calcium ion into cytosol; T cell costimulation; ruffle organization and biogenesis; dendritic cell chemotaxis; establishment of T cell polarity; immune response; positive regulation of cell-matrix adhesion; inflammatory response
Research Articles on SLC
Similar Products
Product Notes
The SLC ccl21 (Catalog #AAA2003479) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Secondary Lymphoid Tissue Chemokine (SLC) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Secondary Lymphoid Tissue Chemokine (SLC) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the SLC ccl21 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF -LALSLL SLVLVLCVPW TQGSDGGGQD CCLRYSQKKI PYNIVRGYRK QEPSLGCPIP AILFAPRKQS QPELCANPEE AWVQKLMRRL DQPPAPGKQN CRKNRGTSKS GKKGRGSKGC KGTEQTDSKR VS. It is sometimes possible for the material contained within the vial of "Secondary Lymphoid Tissue Chemokine (SLC), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
