Testing Data
(Sample (30 ug of whole cell lysate) A: K562 10% SDS PAGE Primary antibody diluted at 1: 1000)
Rabbit anti-Human Sec61 alpha-1 Polyclonal Antibody | anti-Sec61 alpha-1 antibody
Sec61 alpha-1 antibody
Immunohistochemistry: 1:50-1:500
Immunofluorescence: 1:100-1:200
Testing Data
(Sample (30 ug of whole cell lysate) A: K562 10% SDS PAGE Primary antibody diluted at 1: 1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: K562 10% SDS PAGE Primary antibody diluted at 1: 1000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SEC61A1 antibody at 1: 500 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SEC61A1 antibody at 1: 500 dilution.)
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A431, using SEC61A1 antibody at 1: 200 dilution.)
Immunofluorescence (IF)
(Immunofluorescence analysis of methanol-fixed A431, using SEC61A1 antibody at 1: 200 dilution.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008]
Uniprot Description
SEC61A1: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. Belongs to the SecY/SEC61-alpha family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: rough endoplasmic reticulum; membrane; integral to endoplasmic reticulum membrane
Molecular Function: protein binding; ribosome binding
Biological Process: endoplasmic reticulum organization and biogenesis; protein targeting to ER; SRP-dependent cotranslational protein targeting to membrane; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; posttranslational protein targeting to membrane; cell growth
Research Articles on Sec61 alpha-1
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Product Notes
The Sec61 alpha-1 sec61a1 (Catalog #AAA9414909) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Sec61 alpha-1 antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Sec61 alpha-1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:50-1:500 Immunofluorescence: 1:100-1:200. Researchers should empirically determine the suitability of the Sec61 alpha-1 sec61a1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Sec61 alpha-1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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