Western Blot (WB)
(SEC23IP Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SEC23IP antibody detected the SEC23IP protein (arrow).)
Rabbit anti-Human SEC23IP Polyclonal Antibody | anti-SEC23IP antibody
SEC23IP Antibody (C-term)
Western Blot (WB)
(SEC23IP Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SEC23IP antibody detected the SEC23IP protein (arrow).)
Western Blot (WB)
(SEC23IP Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SEC23IP antibody detected the SEC23IP protein (arrow).)
from the endoplasmic reticulum to the Golgi apparatus. The protein
encoded by this gene was identified by its interaction with a mouse
protein similar to yeast Sec23p, an essential component of the
COPII. This protein shares significant similarity with
phospholipid-modifying proteins, especially phosphatidic acid
preferring-phospholipase A1. Overexpression of this protein has
been shown to cause disorganization of the endoplasmic
reticulum-Golgi intermediate compartment and Golgi apparatus, which
suggests its role in the early secretory pathway. [provided by
RefSeq].
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006)
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
SEC23IP: Plays a role in the organization of endoplasmic reticulum exit sites. Belongs to the PA-PLA1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q25-q26
Cellular Component: cis-Golgi network; intracellular membrane-bound organelle; cytoplasm; ER-Golgi intermediate compartment
Molecular Function: metal ion binding
Biological Process: acrosome formation; intracellular protein transport; single fertilization; Golgi organization and biogenesis
Research Articles on SEC23IP
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Product Notes
The SEC23IP sec23ip (Catalog #AAA9202825) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 724-752. The SEC23IP Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SEC23IP can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the SEC23IP sec23ip for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SEC23IP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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