Western Blot (WB)
(Western blot analysis of SCP2 Antibody (Center) in A2058 cell line lysates (35ug/lane). SCP2 (arrow) was detected using the purified Pab.)
Rabbit anti-Human SCP2 Polyclonal Antibody | anti-SCP2 antibody
SCP2, ID (Non-specific Lipid-transfer Protein, Propanoyl-CoA C-acyltransferase, NSL-TP, Sterol Carrier Protein 2, SCP-2, Sterol Carrier Protein X, SCP-X, SCP-chi, SCPX)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Western Blot (WB)
(Western blot analysis of SCP2 Antibody (Center) in A2058 cell line lysates (35ug/lane). SCP2 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of SCP2 Antibody (Center) in A2058 cell line lysates (35ug/lane). SCP2 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SCP2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with SCP2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of HepG2 cells using SCP2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(Flow cytometric analysis of HepG2 cells using SCP2 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.
Uniprot Description
SCP2: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. Defects in SCP2 are a cause of leukoencephalopathy with dystonia and motor neuropathy (LDMN); also known as sterol carrier protein 2 deficiency. LDMN is a syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: Lipid-binding; Lipid Metabolism - primary bile acid biosynthesis; EC 2.3.1.176; Mitochondrial; Transferase
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: nucleoplasm; peroxisomal matrix; protein complex; mitochondrion; intracellular membrane-bound organelle; membrane; cytoplasm; peroxisome
Molecular Function: protein binding; acyl-CoA binding; cholesterol binding; phosphatidylinositol transporter activity; propanoyl-CoA C-acyltransferase activity; receptor binding
Biological Process: bile acid biosynthetic process; progesterone biosynthetic process; bile acid metabolic process; unsaturated fatty acid metabolic process; positive regulation of intracellular cholesterol transport; cellular lipid metabolic process; lipid transport; positive regulation of steroid metabolic process; fatty acid beta-oxidation using acyl-CoA oxidase; inositol trisphosphate biosynthetic process; peroxisome organization and biogenesis; phospholipid transport; steroid biosynthetic process
Disease: Leukoencephalopathy With Dystonia And Motor Neuropathy
Research Articles on SCP2
Similar Products
Product Notes
The SCP2 scp2 (Catalog #AAA623375) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SCP2, ID (Non-specific Lipid-transfer Protein, Propanoyl-CoA C-acyltransferase, NSL-TP, Sterol Carrier Protein 2, SCP-2, Sterol Carrier Protein X, SCP-X, SCP-chi, SCPX) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SCP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in ELISA and Western Blot. Dilution: ELISA: 1:1,000 Western Blot: 1:100-1:500. Researchers should empirically determine the suitability of the SCP2 scp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
