Rabbit anti-Human SCO1 Polyclonal Antibody | anti-SCO1 antibody

SCO1 Rabbit Polyclonal

Cat. Num. AAA7603883

• Gene Names: SCO1; SCOD1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: SCO1; Polyclonal Antibody; SCO1 Rabbit Polyclonal; anti-SCO1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 301

• Applicable Applications for anti-SCO1 antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: SCO cytochrome oxidase deficient homolog 1 (yeast)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver using MBS7603883 (SCO1 antibody) at dilution of 1:100)

Western Blot (WB)

(rat heart tissue were subjected to SDS PAGE followed by western blot with MBS7603883 (SCO1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 823669138
• NCBI GeneID: 6341
• Molecular Weight: 33,814 Da
• NCBI Official Full Name: SCO1, partial
• NCBI Official Synonym Full Names: SCO1 cytochrome c oxidase assembly protein
• NCBI Official Symbol: SCO1
• NCBI Official Synonym Symbols: SCOD1
• NCBI Protein Information: protein SCO1 homolog, mitochondrial
• UniProt Protein Name: Protein SCO1 homolog, mitochondrial
• Protein Family: SCO1 protein
• UniProt Gene Name: SCO1
• UniProt Synonym Gene Names: SCOD1
• UniProt Entry Name: SCO1_HUMAN

NCBI Description

Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]

Uniprot Description

SCO1: Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX. Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the SCO1/2 family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: mitochondrial inner membrane; mitochondrion; myofibril

Molecular Function: copper ion binding; protein binding

Biological Process: cellular copper ion homeostasis; copper ion transport; generation of precursor metabolites and energy; respiratory chain complex IV assembly

Disease: Mitochondrial Complex Iv Deficiency