Rabbit SCN1A Polyclonal Antibody | anti-SCN1A antibody

SCN1A Antibody (Center)

Cat. Num. AAA9231272

• Gene Names: SCN1A; FEB3; FHM3; NAC1; SCN1; SMEI; EIEE6; FEB3A; HBSCI; GEFSP2; Nav1.1
• Reactivity: Human; Predicted: Mouse, Rat
• Applications: Western Blot, ELISA
• Purity: Purified through a protein A column, followed by peptide affinity purification.
• Synonyms: SCN1A; Polyclonal Antibody; SCN1A Antibody (Center); Purified Rabbit Polyclonal Antibody (Pab); Sodium channel protein type 1 subunit alpha; Sodium channel protein brain I subunit alpha; Sodium channel protein type I subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.1; NAC1; SCN1; anti-SCN1A antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse, Rat
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This SCN1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 481-515 amino acids from the Central region of human SCN1A.
• Purity/Purification: Purified through a protein A column, followed by peptide affinity purification.
• Form/Format: Supplied in PBS with 0.09% (W/V) sodium azide.
• Sequence Length: 2009

• Applicable Applications for anti-SCN1A antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:2000
• Antigen Type: Synthesized Peptide
• Antigen Source: Human
• Cellular Location: Cell membrane; Multi-pass membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 2 weeks.; For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-SCN1A Antibody (Center) at 1:2000 dilution + U-87 MG whole cell lysateLysates/proteins at 20 ug per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 229 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-SCN1A antibody

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.

Product Categories/Family for anti-SCN1A antibody

Primary Antibodies; Cardiovascular; Neuroscience; Signal Transduction

References

Escayg A.,et al.Nat. Genet. 24:343-345(2000). Jeong S.-Y.,et al. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases. Sugawara T.,et al. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. Ouchida M.,et al. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases. Hillier L.W.,et al.Nature 434:724-731(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 260166633
• NCBI GeneID: 6323
• NCBI Accession #: NP_001159435.1
• NCBI GenBank Nucleotide #: NM_001165963.2
• UniProt Accession #: P35498; Q16172; Q585T7; Q8IUJ6; Q96LA3; Q9C008; E9PG49
• Molecular Weight: 228972
• NCBI Official Full Name: sodium channel protein type 1 subunit alpha isoform 1
• NCBI Official Synonym Full Names: sodium voltage-gated channel alpha subunit 1
• NCBI Official Symbol: SCN1A
• NCBI Official Synonym Symbols: FEB3; FHM3; NAC1; SCN1; SMEI; EIEE6; FEB3A; HBSCI; GEFSP2; Nav1.1
• NCBI Protein Information: sodium channel protein type 1 subunit alpha
• UniProt Protein Name: Sodium channel protein type 1 subunit alpha
• Protein Family: Sodium channel protein
• UniProt Gene Name: SCN1A
• UniProt Synonym Gene Names: NAC1; SCN1

NCBI Description

Voltage-dependent sodium channels are heteromeric complexes that regulate sodium exchange between intracellular and extracellular spaces and are essential for the generation and propagation of action potentials in muscle cells and neurons. Each sodium channel is composed of a large pore-forming, glycosylated alpha subunit and two smaller beta subunits. This gene encodes a sodium channel alpha subunit, which has four homologous domains, each of which contains six transmembrane regions. Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript. [provided by RefSeq, Oct 2015]

Uniprot Description

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammation and produces hypersensitivity to mechanical, but not thermal stimuli.