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Rabbit anti-Mouse SCF Polyclonal Antibody | anti-SCF antibody

SCF (Stem Cell Factor, CD117 c-kit, Steel Factor, Mast Cell Growth Factor, MGF) (MaxLight 550)

Gene Names
Kitl; Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
Reactivity
Mouse
Applications
Neutralization Assay, Western Blot
Purity
Purified by affinity chromatography from whole serum.
Synonyms
SCF; Polyclonal Antibody; SCF (Stem Cell Factor; CD117 c-kit; Steel Factor; Mast Cell Growth Factor; MGF) (MaxLight 550); anti-SCF antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes mouse Stem Cell Factor (SCF).
Purity/Purification
Purified by affinity chromatography from whole serum.
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight550.
Applicable Applications for anti-SCF antibody
Neutralization, Western Blot (WB), FLISA
Application Notes
Neutralization: 0.60-0.65ug/ml to yield one half maximal inhibition (ND50) of mouse RANTES
WB: 0.1-0.2ug/ml
FLISA: 0.5ug/ml
Applications are based on unconjugated antibody.
Immunogen
Recombinant protein corresponding to mouse SCF.
Conjugate
MaxLight550
Note
Preservative Free
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Product Categories/Family for anti-SCF antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
27,614 Da
NCBI Official Full Name
kit ligand
NCBI Official Synonym Full Names
kit ligand
NCBI Official Symbol
Kitl
NCBI Official Synonym Symbols
Gb; SF; Sl; Clo; Con; Mgf; SCF; SLF; blz; Kitlg; contrasted
NCBI Protein Information
kit ligand; C-kit ligand; Steel factor; cloud gray; grizzle-belly; hematopoietic growth factor KL; mast cell growth factor; stem cell factor
UniProt Protein Name
Kit ligand
Protein Family
UniProt Gene Name
Kitlg
UniProt Synonym Gene Names
Kitl; Mgf; Sl; Slf; MGF; SCF; sKITLG
UniProt Entry Name
SCF_MOUSE

Uniprot Description

SCF: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation. Belongs to the SCF family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: extracellular space; cytoskeleton; membrane; cytoplasm; extracellular region; integral to membrane; plasma membrane

Molecular Function: protein binding; growth factor activity; cytokine activity; stem cell factor receptor binding

Biological Process: embryonic hemopoiesis; positive regulation of leukocyte migration; germ cell programmed cell death; germ cell development; positive regulation of MAP kinase activity; positive regulation of peptidyl-tyrosine phosphorylation; ovarian follicle development; negative regulation of mast cell apoptosis; positive regulation of melanocyte differentiation; positive regulation of cell proliferation; positive regulation of myeloid leukocyte differentiation; positive regulation of Ras protein signal transduction; cell adhesion; neural crest cell migration; positive regulation of DNA replication; negative regulation of apoptosis

Research Articles on SCF

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Product Notes

The SCF kitlg (Catalog #AAA6498588) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SCF (Stem Cell Factor, CD117 c-kit, Steel Factor, Mast Cell Growth Factor, MGF) (MaxLight 550) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SCF can be used in a range of immunoassay formats including, but not limited to, Neutralization, Western Blot (WB), FLISA. Neutralization: 0.60-0.65ug/ml to yield one half maximal inhibition (ND50) of mouse RANTES WB: 0.1-0.2ug/ml FLISA: 0.5ug/ml Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SCF kitlg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SCF, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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