Western Blot (WB)
(SC11A Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SC11A antibody detected the SC11A protein (arrow).)
Rabbit anti-Human SC11A Polyclonal Antibody | anti-SC11A antibody
SC11A, ID (SEC11A, SEC11L1, SPC18, SPCS4A, Signal peptidase complex catalytic subunit SEC11A, Endopeptidase SP18, Microsomal signal peptidase 18kD subunit, SEC11 homolog A, SEC11-like protein 1) (Biotin)
Gene Names
SEC11A; SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
SC11A; Polyclonal Antibody; ID (SEC11A; SEC11L1; SPC18; SPCS4A; Signal peptidase complex catalytic subunit SEC11A; Endopeptidase SP18; Microsomal signal peptidase 18kD subunit; SEC11 homolog A; SEC11-like protein 1) (Biotin); SEC11A; SEC11-like protein 1; anti-SC11A antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Applicable Applications for anti-SC11A antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Immunogen
SC11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the Central region of human SC11A.
Conjugate
Biotin
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Western Blot (WB)
(SC11A Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SC11A antibody detected the SC11A protein (arrow).)
Western Blot (WB)
(SC11A Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the SC11A antibody detected the SC11A protein (arrow).)
Related Product Information for anti-SC11A antibody
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).
Product Categories/Family for anti-SC11A antibody
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007): Dodson, G., et al. Curr. Opin. Struct. Biol. 8(2):189-194(1998).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18,988 Da
NCBI Official Full Name
signal peptidase complex catalytic subunit SEC11A isoform 2
NCBI Official Synonym Full Names
SEC11 homolog A (S. cerevisiae)
NCBI Official Symbol
SEC11A
NCBI Official Synonym Symbols
SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik
NCBI Protein Information
signal peptidase complex catalytic subunit SEC11A; endopeptidase SP18; SEC11-like protein 1; SPase 18 kDa subunit; signal peptidase complex (18kD); microsomal signal peptidase 18 kDa subunit
UniProt Protein Name
Signal peptidase complex catalytic subunit SEC11A
UniProt Gene Name
SEC11A
UniProt Synonym Gene Names
SEC11L1; SPC18; SPCS4A; SPase 18 kDa subunit
UniProt Entry Name
SC11A_HUMAN
NCBI Description
This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
Uniprot Description
SEC11A: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the peptidase S26B family.
Protein type: EC 3.4.21.89; Membrane protein, integral; Protease
Chromosomal Location of Human Ortholog: 15q25.3
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: serine-type peptidase activity
Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translation; signal peptide processing; gene expression; proteolysis; regulation of insulin secretion
Research Articles on SC11A
Similar Products
Product Notes
The SC11A sec11a (Catalog #AAA6345142) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SC11A, ID (SEC11A, SEC11L1, SPC18, SPCS4A, Signal peptidase complex catalytic subunit SEC11A, Endopeptidase SP18, Microsomal signal peptidase 18kD subunit, SEC11 homolog A, SEC11-like protein 1) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SC11A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the SC11A sec11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SC11A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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