Rabbit SATB2 Polyclonal Antibody | anti-SATB2 antibody

SATB2 polyclonal antibody

Cat. Num. AAA3015245

• Gene Names: SATB2; GLSS
• Reactivity: Human, Mouse, Rat, Cow, Horse, Sheep
• Applications: Flow Cytometry, Functional Assay
• Purity: affinity purified by Protein A
• Synonyms: SATB2; Polyclonal Antibody; SATB2 polyclonal antibody; DNA binding protein SATB2; DNA-binding protein SATB2; FLJ21474; FLJ32076; KIAA1034; MGC119474; MGC119477; SATB family member 2; SATB homeobox 2; SATB2_HUMAN; Special AT rich sequence binding protein 2; Special AT-rich sequence-binding protein 2. ; anti-SATB2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat, Cow, Horse, Sheep
• Clonality: Polyclonal
• Specificity: SATB2 Polyclonal Antibody detects endogenous levels of SATB2 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-SATB2 antibody: Flow Cytometry (FC/FACS/FCM)
• Application Notes: FC/FACS/FCM: 1ug/test
• Immunogen: KLH conjugated synthetic peptide derived from human SATB2:451-485/733
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Related Product Information for anti-SATB2 antibody

SATB2 is a nuclear matrix protein that influences craniofacial formation mechanisms, such as jaw and palate development, and is part of a transcriptional network regulating skeletal development and osteoblast differentiation. Highly expressed in adult and fetal brain, SATB2 contains two CUT DNA-binding domains and one homeobox domain and is closely related to SATB1, a transcriptional repressor. SATB2 is thought to bind to matrix-attachment regions (MARs) and regulate MAR-dependent transcription of various genes, including HoxA2 and ATF4 (CREB-2), involved in skeletal development. Functioning as both a transcriptional activator and repressor, SATB2 can also act as a protein scaffold that can enhance the activity of other DNA-binding proteins. Defects in the gene encoding SATB2 are the cause of cleft palate manifested in conjunction with severe mental retardation.

NCBI and Uniprot Product Information

• NCBI GI #: 13634020
• NCBI GeneID: 23314
• UniProt Accession #: Q9UPW6; Q3ZB87; Q4V763; A8K5Z8
• Molecular Weight: 69,137 Da
• NCBI Official Full Name: DNA-binding protein SATB2
• NCBI Official Synonym Full Names: SATB homeobox 2
• NCBI Official Symbol: SATB2
• NCBI Official Synonym Symbols: GLSS
• NCBI Protein Information: DNA-binding protein SATB2; SATB family member 2; special AT-rich sequence-binding protein 2
• UniProt Protein Name: DNA-binding protein SATB2
• Protein Family: DNA-binding protein
• UniProt Gene Name: SATB2
• UniProt Synonym Gene Names: KIAA1034
• UniProt Entry Name: SATB2_HUMAN

NCBI Description

This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]

Uniprot Description

SATB2: Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Chromosomal aberrations involving SATB2 are found in isolated cleft palate. Translocation t(2;7); translocation t(2;11). Defects in SATB2 are a cause of cleft palate isolated (CPI). A congenital fissure of the soft and/or hard palate, due to faulty fusion. Isolated cleft palate is not associated with cleft lips. Some patients may manifest other craniofacial dysmorphic features, mental retardation, and osteoporosis. A chromosomal aberration involving SATB2 is found in a patient with classical features of Toriello-Carey syndrome. Translocation t(2;14)(q33;q22). Belongs to the CUT homeobox family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: nucleoplasm; transcription factor complex; nuclear matrix; cytoplasm; histone deacetylase complex

Molecular Function: protein binding; sequence-specific DNA binding; chromatin binding

Biological Process: chromatin remodeling; transcription, DNA-dependent; commitment of a neuronal cell to a specific type of neuron in the forebrain; cartilage development; neuron migration; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; palate development; embryonic pattern specification; osteoblast development; embryonic skeletal morphogenesis

Disease: Glass Syndrome