Rabbit anti-Human SAMD8 Polyclonal Antibody | anti-SAMD8 antibody

SAMD8 Antibody

Cat. Num. AAA7050743

• Gene Names: SAMD8; SMSr; HEL-177
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G purified
• Synonyms: SAMD8; Polyclonal Antibody; SAMD8 Antibody; Sphingomyelin synthase-related protein 1; SMSr; Ceramide phosphoethanolamine synthase; CPE synthase; Sterile alpha motif domain-containing protein 8; SAM domain-containing protein 8; anti-SAMD8 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 415

• Applicable Applications for anti-SAMD8 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1: 20-1: 200
• Immunogen: Recombinant Human Sphingomyelin synthase-related protein 1 protein (1-152AA)
• Preservative: 0.03% Proclin 300
• Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Conjugation: Non-conjugated
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-139050
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human lymph node tissue using MBS7050743 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7050743 at dilution of 1:100)

Related Product Information for anti-SAMD8 antibody

Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 292658773
• NCBI GeneID: 142891
• NCBI Accession #: NP_001167627.1
• NCBI GenBank Nucleotide #: NM_001174156.1
• UniProt Accession #: Q96LT4; Q5JSC5; Q5JSC8; Q66K52
• Molecular Weight: 37,609 Da
• NCBI Official Full Name: sphingomyelin synthase-related protein 1 isoform 1
• NCBI Official Synonym Full Names: sterile alpha motif domain containing 8
• NCBI Official Symbol: SAMD8
• NCBI Official Synonym Symbols: SMSr; HEL-177
• NCBI Protein Information: sphingomyelin synthase-related protein 1
• UniProt Protein Name: Sphingomyelin synthase-related protein 1
• Protein Family: Sphingomyelin synthase-related protein
• UniProt Gene Name: SAMD8
• UniProt Synonym Gene Names: SMSr; CPE synthase; SAM domain-containing protein 8
• UniProt Entry Name: SAMD8_HUMAN

Uniprot Description

SAMD8: Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. Belongs to the sphingomyelin synthase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: integral to endoplasmic reticulum membrane; integral to Golgi membrane; integral to plasma membrane

Molecular Function: ceramide cholinephosphotransferase activity; sphingomyelin synthase activity

Biological Process: ceramide biosynthetic process