Rabbit anti-Human SAA1 / SAA / Serum Amyloid A Polyclonal Antibody | anti-SAA1 antibody

Rabbit Polyclonal (IgG) to Human SAA1 / SAA / Serum Amyloid A

Cat. Num. AAA248190

• Gene Names: SAA1; SAA; PIG4; SAA2; TP53I4
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: SAA1 / SAA / Serum Amyloid A; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human SAA1 / SAA / Serum Amyloid A; Anti-SAA1 / SAA / Serum Amyloid A Antibody (aa1-106) IHC-plus; SAA1; Serum amyloid A protein; Serum Amyloid A; Serum amyloid A-1 protein; TP53I4; SAA; Serum amyloid A1; PIG4; Human SAA1; anti-SAA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human SAA1 / SAA / Serum Amyloid A
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 122

• Applicable Applications for anti-SAA1 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB
• Target Species: Human
• Immunogen Description: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 106 of SAA1. Percent identity by BLAST analysis: Human (100%).
• Immunogen Species: SAA1/SAA/Serum Amyloid A antibody was raised against Human
• Antigen Type: Recombinant protein
• Recommended Storage: Upon arival: Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.
• Immunogen Type: Recombinant protein
• Immunogen: SAA1 / SAA / Serum Amyloid A antibody was raised against recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 106 of SAA1. Percent identity by BLAST analysis: Human (100%).
• Antigen Modification: aa1-106
• Preparation and Storage: Keep as concentrated solution. Aliquot and store at -20 degree C or below. Avoid multiple freeze-thaw cycles.

Immunohistochemistry (IHC)

(Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-SAA1 antibody

Serum Amyloid A1 (SAA1), a member of the serum amyloid A family of apolipoproteins, is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. It also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of SAA1 are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn s disease. SAA1 may also be a potential biomarker for certain tumors.

NCBI and Uniprot Product Information

• NCBI GI #: 40316912
• NCBI GeneID: 6288
• NCBI Accession #: NP_000322.2
• NCBI GenBank Nucleotide #: NM_000331.4
• UniProt Accession #: P02735; P02736; P02737; Q16730; Q16834; Q16835; Q16879; Q3KRB3; Q6FG67; Q96QN0; Q9UCK9; P0DJI8
• Molecular Weight: 13,532 Da
• NCBI Official Full Name: serum amyloid A-1 protein preproprotein
• NCBI Official Synonym Full Names: serum amyloid A1
• NCBI Official Symbol: SAA1
• NCBI Official Synonym Symbols: SAA; PIG4; SAA2; TP53I4
• NCBI Protein Information: serum amyloid A-1 protein; serum amyloid A protein; tumor protein p53 inducible protein 4
• UniProt Protein Name: Serum amyloid A-1 protein
• Protein Family: Serum amyloid A-1 protein
• UniProt Gene Name: SAA1
• UniProt Synonym Gene Names: SAA
• UniProt Entry Name: SAA1_HUMAN

NCBI Description

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]

Uniprot Description

SAA1: Major acute phase reactant. Apolipoprotein of the HDL complex. Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Elevated serum SAA1 protein levels may be associated with lung cancer. Belongs to the SAA family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: extracellular region

Molecular Function: heparin binding; G-protein-coupled receptor binding

Biological Process: positive regulation of interleukin-1 secretion; neutrophil chemotaxis; receptor-mediated endocytosis; platelet activation; elevation of cytosolic calcium ion concentration; positive regulation of cell adhesion; regulation of protein secretion; negative regulation of inflammatory response; acute-phase response; innate immune response; lymphocyte chemotaxis; macrophage chemotaxis; positive regulation of cytokine secretion