Rabbit S100B Polyclonal Antibody | anti-S100B antibody

S100B Polyclonal Antibody

Cat. Num. AAA2568143

• Gene Names: S100b; Bpb; AI850290
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen Affinity Purification
• Synonyms: S100B; Polyclonal Antibody; S100B Polyclonal Antibody; NEF; Protein S100 B; S 100 calcium binding protein beta chain; S100 protein beta chain; S-100 protein subunit beta; S100; S100 calcium-binding protein B; S100beta; anti-S100B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
• Concentration: 0.3mg/mL (varies by lot)

• Applicable Applications for anti-S100B antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant Mouse Protein S100-B protein
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immununohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human breast cancer using S100B Polycloanl Antibody at dilution of 1:50)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Mouse brain using S100B Polycloanl Antibody at dilution of 1:50)

Immunohistochemsitry (IHC)]

(Immunohistochemistry of paraffin-embedded Rat brain using S100B Polycloanl Antibody at dilution of 1:50)

Related Product Information for anti-S100B antibody

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly.

Product Categories/Family for anti-S100B antibody

Cell Biology; Epigenetics and Nuclear Signaling; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 6677839
• NCBI GeneID: 20203
• NCBI Accession #: NP_033141.1
• NCBI GenBank Nucleotide #: NM_009115.3
• UniProt Accession #: P50114
• Molecular Weight: 10,728 Da
• NCBI Official Full Name: protein S100-B
• NCBI Official Synonym Full Names: S100 protein, beta polypeptide, neural
• NCBI Official Symbol: S100b
• NCBI Official Synonym Symbols: Bpb; AI850290
• NCBI Protein Information: protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B
• UniProt Protein Name: Protein S100-B
• Protein Family: Protein
• UniProt Gene Name: S100b
• UniProt Entry Name: S100B_MOUSE

Uniprot Description

S100B: Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. The S100B dimer binds two molecules of STK38. Interacts with AGER. The S100B dimer interacts with two molecules of CAPZA1. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Belongs to the S-101 family.

Protein type: Calcium-binding

Cellular Component: ruffle; extracellular space; intracellular membrane-bound organelle; cell soma; perinuclear region of cytoplasm; cytoplasm; extracellular region; nucleus

Molecular Function: identical protein binding; RAGE receptor binding; protein homodimerization activity; zinc ion binding; metal ion binding; calcium ion binding; calcium-dependent protein binding; receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; cellular calcium ion homeostasis; regulation of cell shape; learning and/or memory; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of apoptosis; positive regulation of cell proliferation; energy reserve metabolic process; positive regulation of synaptic transmission; memory; regulation of cytokine biosynthetic process; regulation of neuronal synaptic plasticity