Rabbit anti-Human RUSC2 Polyclonal Antibody | anti-RUSC2 antibody

RUSC2 Antibody

Cat. Num. AAA9401241

• Gene Names: RUSC1; NESCA
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: RUSC2; Polyclonal Antibody; RUSC2 Antibody; RUN and SH3 domain containing protein 2; Iporin; anti-RUSC2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: At least three isoforms are known to exist; this antibody will only detect the longest isoform. This antibody is predicted to not cross-react with RUSC1.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 902

• Applicable Applications for anti-RUSC2 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 15 amino acid peptide from near the carboxy terminus of human RUSC2.
• Target Name: RUSC2
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Immunohistochemistry (IHC)

(Immunohistochemistry of RUSC2 in human placenta tissue with RUSC2 antibody at 5 ug/mL.)

Related Product Information for anti-RUSC2 antibody

RUSC2, also known as Iporin, shares with the related protein RUSC1 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC2 is a rab1-interacting protein that also interacts with GM130, another rab1-interacting protein. RUSC2 interacts with specific rab1 isoforms with different rab-binding specificity. It has been suggested that RUSC2 may function as a link between the targeting of ER derived vesicles triggered by the rab1 GTPase and a signaling pathway composed of proteins containing SH3 and/or poly-proline regions.

Product Categories/Family for anti-RUSC2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 157412245
• NCBI GeneID: 23623
• NCBI Accession #: NP_001098673
• NCBI GenBank Nucleotide #: NM_001105203.1
• Molecular Weight: 85,216 Da
• NCBI Official Full Name: RUN and SH3 domain-containing protein 1 isoform a
• NCBI Official Synonym Full Names: RUN and SH3 domain containing 1
• NCBI Official Symbol: RUSC1
• NCBI Official Synonym Symbols: NESCA
• NCBI Protein Information: RUN and SH3 domain-containing protein 1
• UniProt Protein Name: RUN and SH3 domain-containing protein 1
• Protein Family: Iporin
• UniProt Gene Name: RUSC1
• UniProt Synonym Gene Names: NESCA; Nesca
• UniProt Entry Name: RUSC1_HUMAN

Uniprot Description

RUSC1: Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: microtubule cytoskeleton; Golgi apparatus; microtubule; postsynaptic membrane; early endosome; cytoplasmic membrane-bound vesicle; cytoplasm; postsynaptic density; cytoplasmic vesicle; nucleus; cell junction

Molecular Function: protein binding; SH3/SH2 adaptor activity; actin binding

Biological Process: protein polyubiquitination; positive regulation of signal transduction