Rabbit RUNX2 Polyclonal Antibody | anti-RUNX2 antibody
RUNX2 Antibody BIOTIN-Conjugated
Gene Names
LOC703331; RUNX2
Reactivity
Bovine, Human, Monkey, Panda
Applications
ELISA, Western Blot
Synonyms
RUNX2; Polyclonal Antibody; RUNX2 Antibody BIOTIN-Conjugated; Acute myeloid leukemia 3 protein; Alpha subunit 1; AML3; CBF alpha 1; CBFA1; CCD1; Cleidocranial dysplasia 1; Core binding factor runt domain alpha subunit 1; Core binding factor subunit alpha 1; Oncogene AML 3; OSF 2; Osteoblast specific transcription factor 2; PEBP2 alpha A; PEBP2A1; PEBP2A2; Polyomavirus enhancer-binding protein 2 alpha A subunit; Runt domain; Runt related transcription factor 2 antibody SL3 3 enhancer factor 1 alpha A subunit antibody; anti-RUNX2 antibody
Host
Rabbit
Reactivity
Bovine, Human, Monkey, Panda
Clonality
Polyclonal
Form/Format
BIOTIN-Conjugated
Concentration
0.53 ug/ul in antibody stabilization buffer (varies by lot)
Applicable Applications for anti-RUNX2 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
ELISA: 1:10,000
Western Blot: 1:500
Immunogen
Synthetic peptide taken within amino acid region 10-50 on human RUNX2 protein.
Molecular Function
DNA-binding; Transcription Regulation
Structure
Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with HIVEP3. Interacts with IFI204. I
Subcellular Location
Nucleus
Preparation and Storage
-20 degree C for long term storage
Related Product Information for anti-RUNX2 antibody
BIOTIN-Conjugated Runt-related transcription factor 2 isoform 4 Antibody
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Symbol
LOC703331
NCBI Official Synonym Symbols
RUNX2
NCBI Protein Information
runt-related transcription factor 2
Protein Family
Similar Products
Product Notes
The RUNX2 (Catalog #AAA544749) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RUNX2 Antibody BIOTIN-Conjugated reacts with Bovine, Human, Monkey, Panda and may cross-react with other species as described in the data sheet. AAA Biotech's RUNX2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Western Blot: 1:500. Researchers should empirically determine the suitability of the RUNX2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RUNX2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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