Rabbit anti-Human, Mouse RPS6KA4 Polyclonal Antibody | anti-RPS6KA4 antibody

RPS6KA4 (Ab-568) Antibody

Cat. Num. AAA7130620

• Gene Names: RPS6KA4; MSK2; RSK-B
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: RPS6KA4; Polyclonal Antibody; RPS6KA4 (Ab-568) Antibody; EC 2.7.11.1; kinase MSK2; KS6A4; Ribosomal protein kinase B; anti-RPS6KA4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; Rabbit IgG In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-RPS6KA4 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:3000
• Immunogen: Synthesized non-phosphopeptide derived from human MSK2 around the phosphorylation site of threonine 568 (M-Q-T(p)-P-C).
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blot analysis of extracts from RAW264.7 cells, treated with UV (5mins), using MSK2 (Ab-568) antibody. )

Product Categories/Family for anti-RPS6KA4 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 55743138
• NCBI GeneID: 8986
• NCBI Accession #: NP_001006945.1
• NCBI GenBank Nucleotide #: NM_001006944.1
• UniProt Accession #: O75676; O75585; Q53ES8; A8K7Z8
• Molecular Weight: 85,606 Da
• NCBI Official Full Name: ribosomal protein S6 kinase alpha-4 isoform b
• NCBI Official Synonym Full Names: ribosomal protein S6 kinase, 90kDa, polypeptide 4
• NCBI Official Symbol: RPS6KA4
• NCBI Official Synonym Symbols: MSK2; RSK-B
• NCBI Protein Information: ribosomal protein S6 kinase alpha-4; RSKB; S6K-alpha-4; ribosomal protein kinase B; ribosomal protein S6 kinase alpha 4; 90 kDa ribosomal protein S6 kinase 4; mitogen- and stress-activated protein kinase 2; nuclear mitogen- and stress-activated protein ki
• UniProt Protein Name: Ribosomal protein S6 kinase alpha-4
• Protein Family: Ribosomal protein S6 kinase
• UniProt Gene Name: RPS6KA4
• UniProt Synonym Gene Names: MSK2; S6K-alpha-4; RSKB
• UniProt Entry Name: KS6A4_HUMAN

NCBI Description

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

MSK2: an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Phosphorylates H3 and HMG-14 in response to growth factors and cellular stress.

Protein type: EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; MSK subfamily

Chromosomal Location of Human Ortholog: 11q11-q13

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; mitogen-activated protein kinase p38 binding; magnesium ion binding; ribosomal protein S6 kinase activity; ATP binding

Biological Process: axon guidance; regulation of transcription, DNA-dependent; positive regulation of histone phosphorylation; histone phosphorylation; negative regulation of cytokine production; activation of CREB transcription factor; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; protein amino acid phosphorylation; activation of NF-kappaB transcription factor