Rabbit RPLP1 Polyclonal Antibody | anti-RPLP1 antibody

RPLP1 Rabbit pAb

Cat. Num. AAA4759016

• Gene Names: RPLP1; P1; LP1; RPP1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: RPLP1; Polyclonal Antibody; RPLP1 Rabbit pAb; ribosomal protein; large; P1; LP1; RPP1; anti-RPLP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.3mg/ml (varies by lot)

• Applicable Applications for anti-RPLP1 antibody: Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: WB: 1:200-1:1000; IHC-P: 1:25-1:100
• Immunogen: Fusion protein of human RPLP1
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of RPLP1 in K562 and hepg2 cells in order using RPLP1 Rabbit pAb at dilution 1/400)

Immunohistochemistry (IHC)

(Immunohistochemistry of RPLP1 in paraffin-embedded Human gasrtic cancer tissue using RPLP1 Rabbit pAb at dilution 1/25. Predicted cell location: Nucleus)

Related Product Information for anti-RPLP1 antibody

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E Coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

NCBI and Uniprot Product Information

• NCBI GI #: 4506669
• NCBI GeneID: 6176
• NCBI Accession #: NP_000994.1
• NCBI GenBank Nucleotide #: NM_001003.2
• UniProt Accession #: P05386; A6NIB2
• Molecular Weight: 8,804 Da
• NCBI Official Full Name: 60S acidic ribosomal protein P1 isoform 1
• NCBI Official Synonym Full Names: ribosomal protein, large, P1
• NCBI Official Symbol: RPLP1
• NCBI Official Synonym Symbols: P1; LP1; RPP1
• NCBI Protein Information: 60S acidic ribosomal protein P1; acidic ribosomal phosphoprotein P1
• UniProt Protein Name: 60S acidic ribosomal protein P1
• UniProt Gene Name: RPLP1
• UniProt Synonym Gene Names: RRP1
• UniProt Entry Name: RLA1_HUMAN

NCBI Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Uniprot Description

RPLP1: Plays an important role in the elongation step of protein synthesis. Belongs to the ribosomal protein L12P family.

Protein type: Translation; Ribosomal

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: focal adhesion; cytoplasm; cytosol

Molecular Function: protein binding; structural constituent of ribosome; RNA binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; translational elongation; cellular protein metabolic process; viral reproduction; translation; mRNA catabolic process, nonsense-mediated decay; translational initiation; viral transcription; gene expression; viral infectious cycle; translational termination