Goat RPL22 / L22 Polyclonal Antibody | anti-RPL22 antibody

Goat Polyclonal to Human RPL22 / L22

Cat. Num. AAA247320

• Gene Names: RPL22; EAP; L22; HBP15; HBP15/L22
• Reactivity: Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat; Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: RPL22 / L22; Polyclonal Antibody; Goat Polyclonal to Human RPL22 / L22; Anti-RPL22 / L22 Antibody (C-Terminus) IHC-plus; RPL22; 60S ribosomal protein L22; EAP; EBER-associated protein; HBP15; Heparin-binding protein 15; Ribosomal protein L22; Heparin-binding protein HBp15; L22; Human RPL22; anti-RPL22 antibody

• Host: Goat
• Reactivity: Gibbon, Bovine, Chicken, Dog, Xenopus, Gorilla, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat; Predicted Reactivity: Zebrafish (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human RPL22.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 128

• Applicable Applications for anti-RPL22 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:16000), IHC-P (3.75 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-SKESYELRYFQINQ from the C-terminus of human RPL22 (NP_000974.1).
• Immunogen Type: Synthetic peptide
• Immunogen: RPL22 / L22 antibody was raised against synthetic peptide C-SKESYELRYFQINQ from the C-terminus of human RPL22 (NP_000974.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Bovine, Dog, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Platypus, Xenopus (100%); Panda, Seabass, Catfish, Salmon, Sablefish, Stickleback, Pike, Zebrafish (93%); Seq squirt, Eye worm, Nematode (86%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-RPL22 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-RPL22 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-RPL22 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-RPL22 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4506613
• NCBI GeneID: 6146
• NCBI Accession #: NP_000974.1
• NCBI GenBank Nucleotide #: NM_000983.3
• UniProt Accession #: P35268; Q6IBD1; B2R495
• Molecular Weight: 14,787 Da
• NCBI Official Full Name: 60S ribosomal protein L22 proprotein
• NCBI Official Synonym Full Names: ribosomal protein L22
• NCBI Official Symbol: RPL22
• NCBI Official Synonym Symbols: EAP; L22; HBP15; HBP15/L22
• NCBI Protein Information: 60S ribosomal protein L22; EBER-associated protein; heparin-binding protein 15; heparin-binding protein HBp15; Epstein-Barr-encoded RNA-associated protein; Epstein-Barr virus small RNA-associated protein
• UniProt Protein Name: 60S ribosomal protein L22
• Protein Family: 50S ribosomal protein
• UniProt Gene Name: RPL22
• UniProt Synonym Gene Names: EAP
• UniProt Entry Name: RL22_HUMAN

NCBI Description

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

Uniprot Description

RPL22: a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2. [provided by RefSeq, Jul 2008]

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 1p36.31

Cellular Component: focal adhesion; cytoplasm; cytosol; nucleus; ribonucleoprotein complex

Molecular Function: heparin binding; protein binding; structural constituent of ribosome; RNA binding

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translational elongation; viral reproduction; translation; mRNA catabolic process, nonsense-mediated decay; translational initiation; alpha-beta T cell differentiation; viral transcription; gene expression; translational termination; viral infectious cycle