Western Blot (WB)
(Western Blot analysis of cell extracts from HEK293 cells overexpressing DYKDDDDK-tagged mouse ROR2, using MBS618560 (upper) and anti-DYKDDDDK tag antibody (lower).)
Rabbit anti-Human, Mouse ROR2 Polyclonal Antibody | anti-ROR2 antibody
ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2, BDB, BDB1, MGC163394, Neurotrophic Tyrosine Kinase, Receptor-related 2, NTRKR2, Tyrosine-protein Kinase Transmembrane Receptor ROR2)
Purified by Protein A and immunoaffinity chromatography
Purified by Protein A and immunoaffinity chromatography
Dilution: Western Blot: 1:1000
Immunoprecipitation: 1:50
Western Blot (WB)
(Western Blot analysis of cell extracts from HEK293 cells overexpressing DYKDDDDK-tagged mouse ROR2, using MBS618560 (upper) and anti-DYKDDDDK tag antibody (lower).)
Western Blot (WB)
(Western Blot analysis of cell extracts from HEK293 cells overexpressing DYKDDDDK-tagged mouse ROR2, using MBS618560 (upper) and anti-DYKDDDDK tag antibody (lower).)
Immunocytochemistry (ICC)
(Immunocytofluorescence staining of HEK293 cells (left) and HEK293 cells overexpressing mouse ROR2 (right), using MBS618560.)
Immunocytochemistry (ICC)
(Immunocytofluorescence staining of HEK293 cells (left) and HEK293 cells overexpressing mouse ROR2 (right), using MBS618560.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq]
Uniprot Description
ROR2: a receptor tyrosine kinase of the ROR family. May be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
Protein type: Kinase, protein; EC 2.7.10.1; Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; Ror family
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: Wnt-protein binding; protein binding; frizzled binding; transmembrane receptor protein tyrosine kinase activity; ATP binding
Biological Process: inner ear morphogenesis; somitogenesis; peptidyl-tyrosine phosphorylation; Wnt receptor signaling pathway, planar cell polarity pathway; positive regulation of transcription, DNA-dependent; multicellular organismal development; signal transduction; negative regulation of cell proliferation; Wnt receptor signaling pathway, calcium modulating pathway; JNK cascade; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; cartilage condensation; embryonic genitalia morphogenesis
Disease: Robinow Syndrome, Autosomal Recessive; Brachydactyly, Type B1
Research Articles on ROR2
2. Data showed a correlation between the severity of BDB1, the location of the mutation, and the amount of membrane-associated ROR2.
3. The deletion represents the second ROR2 mutation associated with a autosomal dominant brachydactyly type B1-syndactyly phenotype.
4. Data show that ROR2 knockdown results in a decrease in signaling downstream of Wnt5A.
5. Distal symphalangism affecting only 4th finger with ROR2 mutation.
6. Results indicate that Wnt5a/Ror2 signaling involves the activation of a SFK, leading to MMP-13 expression, and that constitutively active Wnt5a/Ror2 signaling confers invasive properties on osteosarcoma cells in a cell-autonomous manner.
7. Expression of MMP2 in RCC cells was suppressed by Ror2 knockdown, placing Ror2 as a mediator of MMP2 regulation in RCC and a potential regulator of extracellular matrix remodeling.
8. the interaction of Ror2 with BRIb is specific and independent of post-translational N-glycosylation.
9. both Wnt5a and Wnt3a bound Ror2, only Wnt5a induced Ror2 homo-dimerization and tyrosine phosphorylation in U2OS human osteoblastic cells.
10. Stimulation of epithelia by the CaSR increased the expression of the tyrosine kinase Ror2, suggesting existence of a unique paracrine relationship for CDX2 homoeostasis in the intestine.
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Product Notes
The ROR2 ror2 (Catalog #AAA618560) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ROR2 (Receptor Tyrosine Kinase-like Orphan Receptor 2, BDB, BDB1, MGC163394, Neurotrophic Tyrosine Kinase, Receptor-related 2, NTRKR2, Tyrosine-protein Kinase Transmembrane Receptor ROR2) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's ROR2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Suitable for use in Western Blot and Immunoprecipitation. Dilution: Western Blot: 1:1000 Immunoprecipitation: 1:50. Researchers should empirically determine the suitability of the ROR2 ror2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ROR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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