Western Blot
( Western Blot with MDA cells. 1:500 antibody dilutions in DiluObuffer. Apparent MVV is 128 kDa.)
Rabbit ROR1 Polyclonal Antibody | anti-ROR1 antibody
Rabbit Polyclonal Anti-ROR1 antibody BIOTIN
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:500
Sequence: TVKGNKSQKPYKIDSKQAS
Western Blot
( Western Blot with MDA cells. 1:500 antibody dilutions in DiluObuffer. Apparent MVV is 128 kDa.)
Western Blot
( Western Blot with MDA cells. 1:500 antibody dilutions in DiluObuffer. Apparent MVV is 128 kDa.)
Overview: Receptor tyrosine kinase-like Orphan Receptor (ROR) proteins are conserved tyrosine kinase receptors that pattern tissues and organs during embryonic development and in adulthood. ROR family proteins are ligand-dependent transcription factors that are required for skeleton and neuronal development, and modulate cell migration, cell polarity, and convergent extension. RORs act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated by the adapter protein disheveled and the non-receptor tyrosine kinase Src(1). The mammalian ROR family of receptor tyrosine kinases consists of two structurally related proteins.
MBS544741 is an orphan cell surface receptor with strong homology to the tyrosine kinase domain of growth factorreceptors, in particular the Trk family. MBS544741 is expressed by many tissues during embryogenesis, some 8-cell malignancies, and various cancer cell lines with high levels of phosphorylated AKT and phosphorylated cAMP response element binding-factor. MBS544741 plays a functional role in promoting tumor cell growth, suggesting that this orphan-receptor tyrosine-kinase-like protein may be a potential target for therapy directed against a variety of human cancers (2). High-level expression of MBS544741 is found in breast adenocarcinoma associated with aggressive disease indicating it to be a potential target for breast cancer therapy (3). The MBS544741 gene is mapped to chromosome 1 p12-p32
MBS544741 -selective antibodies were generated against a peptide taken the C-terminal region of the MBS544741 protein. TheMBS544741 -selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Uniprot Description
ROR1: Tyrosine-protein kinase receptor whose role is not yet clear. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, tyrosine (receptor); Membrane protein, integral; Kinase, protein; Protein kinase, TK; EC 2.7.10.1; TK group; Ror family
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity; Wnt-protein binding
Biological Process: peptidyl-tyrosine phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway
Research Articles on ROR1
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Product Notes
The ROR1 ror1 (Catalog #AAA544741) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal Anti-ROR1 antibody BIOTIN reacts with Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ROR1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunoprecipitation: 1:200 Western Blot: 1:500. Researchers should empirically determine the suitability of the ROR1 ror1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ROR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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