Western Blot (WB)
(Western blot analysis of lysates from 293T cell line, human brain tissue lysate (from left to right), using RNT2 Antibody (N-term). MBS9201427 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.)
Rabbit anti-Human RNT2 Polyclonal Antibody | anti-RNASET2 antibody
RNT2 Antibody (N-term)
IHC-P~~1:50~100
Western Blot (WB)
(Western blot analysis of lysates from 293T cell line, human brain tissue lysate (from left to right), using RNT2 Antibody (N-term). MBS9201427 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.)
Western Blot (WB)
(Western blot analysis of lysates from 293T cell line, human brain tissue lysate (from left to right), using RNT2 Antibody (N-term). MBS9201427 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.)
Immunohistochemistry (IHC)
(RNT2 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RNT2 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(RNT2 antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human spleen carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RNT2 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a
single copy gene that maps to 6q27, a region associated with human
malignancies and chromosomal rearrangement.
Quan, C., et al. Nat. Genet. 42(7):614-618(2010)
Liu, J., et al. J. Cell. Mol. Med. 14(5):1146-1155(2010)
Henneke, M., et al. Nat. Genet. 41(7):773-775(2009)
Monti, L., et al. Oncol. Res. 17(2):69-74(2008)
NCBI and Uniprot Product Information
NCBI Description
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
Uniprot Description
RNASET2: Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly (LCWM). An infantile- onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications. Belongs to the RNase T2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ribonuclease; EC 3.1.27.-; RNA-binding; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 6q27
Cellular Component: extracellular space; lysosomal lumen; lysosome; endoplasmic reticulum lumen; extracellular region
Molecular Function: ribonuclease T2 activity; RNA binding; ribonuclease activity
Biological Process: RNA catabolic process
Disease: Leukoencephalopathy, Cystic, Without Megalencephaly
Research Articles on RNASET2
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Product Notes
The RNASET2 rnaset2 (Catalog #AAA9201427) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 25-55. The RNT2 Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RNT2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:500-1:1000 IHC-P~~1:50~100. Researchers should empirically determine the suitability of the RNASET2 rnaset2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RNT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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