Rabbit anti-Human RICTOR Polyclonal Antibody | anti-RICTOR antibody

RICTOR Antibody

Cat. Num. AAA9401270

• Gene Names: RICTOR; PIA; AVO3; hAVO3
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: RICTOR; Polyclonal Antibody; RICTOR Antibody; PIA; AVO3; hAVO3; anti-RICTOR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total RICTOR protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 2 mg/ml (varies by lot)
• Sequence Length: 1732

• Applicable Applications for anti-RICTOR antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:25-1:200
• Immunogen Type: Recombinant Protein
• Immunogen Description: Full length fusion protein
• Target Name: RICTOR
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/50.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/50.)

Related Product Information for anti-RICTOR antibody

Rapamycin-insensitive companion of mTOR is a protein that in humans is encoded by the RICTOR gene. RICTOR and MTOR are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors.

Product Categories/Family for anti-RICTOR antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 550544217
• NCBI GeneID: 253260
• NCBI Accession #: NP_001272368.1
• NCBI GenBank Nucleotide #: NM_001285439.1
• UniProt Accession #: Q6R327; Q68DT5; Q86UB7; Q8N3A0; Q8NCM6; B2RNX0; B7ZMF7
• Molecular Weight: 195,011 Da
• NCBI Official Full Name: rapamycin-insensitive companion of mTOR isoform 2
• NCBI Official Synonym Full Names: RPTOR independent companion of MTOR, complex 2
• NCBI Official Symbol: RICTOR
• NCBI Official Synonym Symbols: PIA; AVO3; hAVO3
• NCBI Protein Information: rapamycin-insensitive companion of mTOR
• UniProt Protein Name: Rapamycin-insensitive companion of mTOR
• Protein Family: Rapamycin-insensitive companion
• UniProt Gene Name: RICTOR
• UniProt Synonym Gene Names: hAVO3
• UniProt Entry Name: RICTR_HUMAN

NCBI Description

RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]

Uniprot Description

RICTOR: a regulatory binding partner of the kinase mTOR. Part of a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Rictor interacts with Cullin1-Rbx1 to form an E3 ubiquitin ligase complex, and promotes ubiquitination and degradation of SGK1. Shares homology with pianissimo from D. discoidieum, STE20p from S. pombe, and AVO3p from S. cerevisiae.

Protein type: Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: TORC2 complex; cytosol

Molecular Function: protein binding; ribosome binding; protein kinase binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; TOR signaling pathway; nerve growth factor receptor signaling pathway; regulation of protein kinase B signaling cascade; positive regulation of protein kinase B signaling cascade; embryonic development; peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; regulation of actin cytoskeleton organization and biogenesis; T cell costimulation; actin cytoskeleton reorganization; innate immune response; positive regulation of endothelial cell proliferation; vascular endothelial growth factor receptor signaling pathway; positive regulation of TOR signaling pathway