Rabbit anti-Human, Rat RIAM Polyclonal Antibody | anti-APBB1IP antibody

Anti-RIAM antibody

Cat. Num. AAA176332

• Gene Names: APBB1IP; RIAM; INAG1; PREL1; RARP1
• Reactivity: Human, Rat
• Applications: Western Blot, Immunohistochemistry, Immunohistochemistry, Immunocytochemistry
• Purity: Immunogen affinity purified.
• Synonyms: RIAM; Polyclonal Antibody; Anti-RIAM antibody; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; amyloid beta(A4) precursor protein-binding; family B; member 1 interacting protein; AB1IP antibody; Amyloid beta A4 precursor protein binding family B member 1 interacting protein antibody; Amyloid beta precursor protein binding family B member 1 antibody; APBB1 interacting protein 1 antibody; OTTHUMP00000019344 antibody; PREL 1 antibody; PREL1 antibody; Proline rich EVH1 ligand 1 antibody; Proline rich protein 73 antibody; Rap1 GTP interacting adapter molecule antibody; RAP1 interacting adaptor molecule antibody; RARP 1 antibody; RARP1 antibody; Retinoic acid responsive proline rich protein 1 antibody; anti-APBB1IP antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immunogen affinity purified.
• Form/Format: Lyophilized
• Sequence Length: 666

• Applicable Applications for anti-APBB1IP antibody: Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunohistochemistry (IHC) Formalin, Immunocytochemistry ICC
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human APBB1IP (647-666aa EQDFMSDLMKALQKKRGNVS), different from the related rat sequence by one amino acid, and from the related mouse sequence by two amino acids.
• Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
• Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
• Preparation and Storage: At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

Western Blot (WB)

(Anti-RIAM antibody, MBS176332, Western blottingLane 1: Rat Thymus Tissue LysateLane 2: Rat Spleen Tissue LysateLane 3: Rat RAJI Tissue LysateLane 4: HL-60 Cell Lysate )

Immunohistochemistry (IHC)

(Anti-RIAM antibody, MBS176332, IHC(P)IHC(P): Human Tonsil Tissue )

Immunocytochemistry (ICC)

(Anti-RIAM antibody, MBS176332, ICCICC: JURKAT Cell )

Related Product Information for anti-APBB1IP antibody

Description: Rabbit IgG polyclonal antibody for Amyloid beta A4 precursor protein-binding family B member 1-interacting protein(APBB1IP) detection. Tested with WB, IHC-P, IHC-F, ICC in Human, Rat.
Background: APBB1IP(APBB1-Interacting Protein), also called RIAM or RARP1, is a protein that in humans is encoded by the APBB1IP gene. By genomic sequence analysis, Lafuente et al.(2004) mapped the RIAM gene to chromosome 10p12.1. Using promoter-reporter gene assays, Inagaki et al.(2003) found that RARP1 suppressed transcription from AP1 and SRE sites, but not CRE sites, in all cell lines examined. The proline-rich regions of RARP1 suppressed AP1 transactivation. Lafuente et al.(2004) found that RIAM interacted with profilin and VASP, molecules that regulate actin dynamics, as well as with RAP1-GTP.

NCBI and Uniprot Product Information

• NCBI GI #: 74750143
• NCBI GeneID: 54518
• UniProt Accession #: Q7Z5R6; Q8IWS8; Q8IYL7; Q8IZZ7
• Molecular Weight: 18,686 Da
• NCBI Official Full Name: Amyloid beta A4 protein-binding family B member 1-interacting protein
• NCBI Official Synonym Full Names: amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
• NCBI Official Symbol: APBB1IP
• NCBI Official Synonym Symbols: RIAM; INAG1; PREL1; RARP1
• NCBI Protein Information: amyloid beta A4 precursor protein-binding family B member 1-interacting protein; PREL-1; RARP-1; proline-rich protein 73; proline rich EVH1 ligand 1; proline-rich EVH1 ligand 1; APBB1-interacting protein 1; Rap1-interacting adaptor molecule; Rap1-GTP-interacting adaptor molecule; rap1-GTP-interacting adapter molecule; retinoic acid-responsive proline-rich protein 1
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
• Protein Family: Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
• UniProt Gene Name: APBB1IP
• UniProt Synonym Gene Names: PREL1; RARP1; RIAM; PREL-1; RIAM; RARP-1
• UniProt Entry Name: AB1IP_HUMAN

Uniprot Description

RIAM: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin- induced promoter activities through AP1 and SRE. Mediates Rap1- induced adhesion. Belongs to the MRL family.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 10p12.1

Cellular Component: cytoskeleton; focal adhesion; lamellipodium; plasma membrane; cytosol

Molecular Function: protein binding

Biological Process: platelet activation; blood coagulation; signal transduction