Rabbit anti-Human, Mouse Rhodopsin Polyclonal Antibody | anti-OPN1SW antibody

Rhodopsin, Blue (MGC138309, MGC138311, OPSD, Opsin 2, Opsin 2 Rod Pigment, Opsin-2, OPN2, Retinitis Pigmentosa 4, Retinitis Pigmentosa 4 Autosomal Dominant, RP4) (AP)

Cat. Num. AAA6497542

• Gene Names: OPN1SW; BCP; BOP; CBT
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: Rhodopsin; Polyclonal Antibody; Blue (MGC138309; MGC138311; OPSD; Opsin 2; Opsin 2 Rod Pigment; Opsin-2; OPN2; Retinitis Pigmentosa 4; Retinitis Pigmentosa 4 Autosomal Dominant; RP4) (AP); anti-OPN1SW antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Opsin, blue. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.

• Applicable Applications for anti-OPN1SW antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 1:200-1:300 on formalin-fixed, paraffin-embedded mouse retina tissue. Antigen retrieval method recommend is HEIR with steam heat; other fixation and retrieval methods are untested.; Applications are based on unconjugated antibody.
• Immunogen: Recombinant protein corresponding to human blue opsin.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Immunohistochemistry (IHC)

(IHC staining of formalin-fixed, paraffin-embedded mouse retina.)

Product Categories/Family for anti-OPN1SW antibody

Antibodies; G Protein Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 4502387
• NCBI GeneID: 611
• NCBI Accession #: NP_001699.1
• NCBI GenBank Nucleotide #: NM_001708.1
• UniProt Accession #: P03999; Q13877
• Molecular Weight: 39,135 Da
• NCBI Official Full Name: short-wave-sensitive opsin 1
• NCBI Official Synonym Full Names: opsin 1 (cone pigments), short-wave-sensitive
• NCBI Official Symbol: OPN1SW
• NCBI Official Synonym Symbols: BCP; BOP; CBT
• NCBI Protein Information: short-wave-sensitive opsin 1; blue-sensitive opsin; blue cone photoreceptor pigment
• UniProt Protein Name: Short-wave-sensitive opsin 1
• Protein Family: Rhodopsin
• UniProt Gene Name: OPN1SW
• UniProt Synonym Gene Names: BCP; BOP
• UniProt Entry Name: OPSB_HUMAN

NCBI Description

This gene belongs to the G-protein coupled receptor 1 family, opsin subfamily. It encodes the blue cone pigment gene which is one of three types of cone photoreceptors responsible for normal color vision. Defects in this gene are the cause of tritan color blindness (tritanopia). Affected individuals lack blue and yellow sensory mechanisms while retaining those for red and green. Defective blue vision is characteristic. [provided by RefSeq, Jul 2008]

Uniprot Description

OPN1SW: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Defects in OPN1SW are the cause of tritan color blindness (CBT). Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 7q32.1

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity; photoreceptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; phototransduction, visible light; visual perception; phototransduction; retinoid metabolic process; signal transduction; protein-chromophore linkage

Disease: Tritanopia