Rabbit RHOA Polyclonal Antibody | anti-GNAZ antibody

RHOA Conjugated Antibody

Cat. Num. AAA9442325

• Gene Names: GNAZ; gz-alpha
• Reactivity: Human, Mouse, Rat
• Applications: Most Applications
• Synonyms: RHOA; Polyclonal Antibody; RHOA Conjugated Antibody; Ras homolog family member A; ARHA; ARH12; RHO12; RHOH12; anti-GNAZ antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total RHOA protein.
• Form/Format: 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide

• Applicable Applications for anti-GNAZ antibody: Most Applications
• Application Notes: Suggested Dilution:; AF350 conjugated: most applications: 1:50-1:250; AF405 conjugated: most applications: 1:50-1:250; AF488 conjugated: most applications: 1:50-1:250; AF555 conjugated: most applications: 1:50-1:250; AF594 conjugated: most applications: 1:50-1:250; AF647 conjugated: most applications: 1:50-1:250; AF680 conjugated: most applications: 1:50-1:250; AF750 conjugated: most applications: 1:50-1:250; Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1:50-1:1000
• Immunogen: Synthetic peptide corresponding to a region derived from 177-189 amino acids of Human ras homolog family member A
• Conjugation: Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750
• Excitation Emission: AF350: 346nm/442nm
• Preparation and Storage: Store at 4 degree C for 6 months.

Related Product Information for anti-GNAZ antibody

Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

NCBI and Uniprot Product Information

• NCBI GI #: 4504051
• NCBI GeneID: 2781
• NCBI Accession #: NP_002064
• NCBI GenBank Nucleotide #: NM_002073.3
• UniProt Accession #: P19086; Q4QRJ6; B2R6C1
• Molecular Weight: 43.0 kDa (375aa)
• NCBI Official Full Name: guanine nucleotide-binding protein G(z) subunit alpha
• NCBI Official Synonym Full Names: G protein subunit alpha z
• NCBI Official Symbol: GNAZ
• NCBI Official Synonym Symbols: gz-alpha
• NCBI Protein Information: guanine nucleotide-binding protein G(z) subunit alpha
• UniProt Protein Name: Guanine nucleotide-binding protein G(z) subunit alpha
• UniProt Gene Name: GNAZ
• UniProt Entry Name: GNAZ_HUMAN

NCBI Description

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. [provided by RefSeq, Jul 2008]

Uniprot Description

G-alpha(z): Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Belongs to the G-alpha family. G(i/o/t/z) subfamily.

Protein type: Nuclear envelope; Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z))

Chromosomal Location of Human Ortholog: 22q11.22

Cellular Component: endoplasmic reticulum; plasma membrane; heterotrimeric G-protein complex; nuclear envelope; cytosol

Molecular Function: GTPase activity; signal transducer activity; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; receptor signaling protein activity; metabotropic serotonin receptor binding

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein coupled receptor protein signaling pathway; metabolic process; G-protein signaling, adenylate cyclase inhibiting pathway