Western Blot (WB)
(RGS13 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RGS13 antibody detected the RGS13 protein (arrow).)
Rabbit anti-Human RGS13 Polyclonal Antibody | anti-RGS13 antibody
RGS13 Antibody (Center)
Western Blot (WB)
(RGS13 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RGS13 antibody detected the RGS13 protein (arrow).)
Western Blot (WB)
(RGS13 Antibody (Center) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RGS13 antibody detected the RGS13 protein (arrow).)
regulator of G protein signaling (RGS) family. RGS family members
share similarity with S. cerevisiae SST2 and C. elegans egl-10
proteins, which contain a characteristic conserved RGS domain. RGS
proteins accelerate GTPase activity of G protein alpha-subunits,
thereby driving G protein into their inactive GDP-bound form, thus
negatively regulating G protein signaling. RGS proteins have been
implicated in the fine tuning of a variety of cellular events in
response to G protein-coupled receptor activation. The biological
function of this gene, however, is unknown. Two transcript variants
encoding the same isoform exist.
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Bansal, G., et al. J. Immunol. 181(11):7882-7890(2008)
Han, J.I., et al. J. Leukoc. Biol. 79(6):1357-1368(2006)
Islam, T.C., et al. Leukemia 17(9):1880-1890(2003)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist. [provided by RefSeq, Jul 2008]
Uniprot Description
RGS13: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)- alpha.
Protein type: GAPs; GAPs, RGS
Chromosomal Location of Human Ortholog: 1q31.2
Cellular Component: cytoplasm; plasma membrane; cytosol; nucleus
Molecular Function: GTPase activator activity
Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity
Research Articles on RGS13
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Product Notes
The RGS13 rgs13 (Catalog #AAA9203182) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 61-90. The RGS13 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RGS13 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RGS13 rgs13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RGS13, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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