Knockout Validation
(Knockout Validation: Lane 1: Wild-type HepG2 cell lysate;;Lane 2: RBP4 knockout HepG2 cell lysate;;Predicted MW: 21kDa ;Observed MW: 21kDa;Primary Ab: 1ug/ml Rabbit Anti-Bovine RBP4 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
Rabbit anti-Cattle Retinol Binding Protein 4, Plasma (RBP4) Polyclonal Antibody | anti-RBP4 antibody
Biotin-Linked Antibody to Retinol Binding Protein 4, Plasma (RBP4)
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Knockout Validation
(Knockout Validation: Lane 1: Wild-type HepG2 cell lysate;;Lane 2: RBP4 knockout HepG2 cell lysate;;Predicted MW: 21kDa ;Observed MW: 21kDa;Primary Ab: 1ug/ml Rabbit Anti-Bovine RBP4 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type HepG2 cell lysate;;Lane 2: RBP4 knockout HepG2 cell lysate;;Predicted MW: 21kDa ;Observed MW: 21kDa;Primary Ab: 1ug/ml Rabbit Anti-Bovine RBP4 Antibody;Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody;(#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Uniprot Description
RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical 'fundus xerophthalmicus', featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: extracellular space; protein complex; extracellular region; cytosol
Molecular Function: protein binding; protein heterodimerization activity; retinal binding; retinol binding
Biological Process: phototransduction, visible light; retinal metabolic process; embryonic skeletal development; heart development; maintenance of gastrointestinal epithelium; uterus development; glucose homeostasis; response to insulin stimulus; embryonic organ morphogenesis; negative regulation of cardiac muscle cell proliferation; retinol metabolic process; detection of light stimulus involved in visual perception; retinoid metabolic process; female genitalia morphogenesis; cardiac muscle development; response to retinoic acid; urinary bladder development; male gonad development; positive regulation of insulin secretion; vagina development; positive regulation of immunoglobulin secretion; gluconeogenesis; response to ethanol; eye development; embryonic retina morphogenesis in camera-type eye; spermatogenesis; lung development
Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10
Research Articles on RBP4
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Product Notes
The RBP4 rbp4 (Catalog #AAA2002339) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Antibody to Retinol Binding Protein 4, Plasma (RBP4) reacts with Cattle and may cross-react with other species as described in the data sheet. AAA Biotech's Retinol Binding Protein 4, Plasma (RBP4) can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the RBP4 rbp4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Retinol Binding Protein 4, Plasma (RBP4), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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