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Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Retinoid X Receptor g antibody.)

Rabbit Retinoid X Receptor gamma Polyclonal Antibody | anti-RXRG antibody

Retinoid X Receptor gamma Antibody

Gene Names
RXRG; RXRC; NR2B3
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
Retinoid X Receptor gamma; Polyclonal Antibody; Retinoid X Receptor gamma Antibody; Retinoid X Receptor g Antibody; RXRC; retinoid X receptor gamma; anti-RXRG antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total Retinoid X Receptor g protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
340
Applicable Applications for anti-RXRG antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from human Retinoid X Receptor g antibody.
Target Name
Retinoid X Receptor g
Preparation and Storage
Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Retinoid X Receptor g antibody.)

Immunohistochemistry (IHC) (Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Retinoid X Receptor g antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of HuvEc cells, using Retinoid X Receptor g antibody.)

Immunofluorescence (IF) (Immunofluorescence analysis of HuvEc cells, using Retinoid X Receptor g antibody.)

Western Blot (WB)

(Western blot analysis of extracts from HepG2 cells, using Retinoid X Receptor g antibody.)

Western Blot (WB) (Western blot analysis of extracts from HepG2 cells, using Retinoid X Receptor g antibody.)

Western Blot (WB)

(Western blot analysis of extracts from HepG2 cells (Lane 2), using Retinoid X Receptor g antiobdy. The lane on the left is treated with synthesized peptide.)

Western Blot (WB) (Western blot analysis of extracts from HepG2 cells (Lane 2), using Retinoid X Receptor g antiobdy. The lane on the left is treated with synthesized peptide.)
Related Product Information for anti-RXRG antibody
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid By similarity.Hideki Chiba, J. Cell Biol., Nov 1997; 139: 735. KS Miyata, J. Biol. Chem., Sep 1993; 268: 19169 - 19172. Deborah L. Osburn, Mol. Cell. Biol., Aug 2001; 21: 4909 - 4918. Isabelle M. L. Billas, J. Biol. Chem., Mar 2001; 276: 7465 - 7474.
Product Categories/Family for anti-RXRG antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
50,871 Da
NCBI Official Full Name
retinoic acid receptor RXR-gamma isoform c
NCBI Official Synonym Full Names
retinoid X receptor, gamma
NCBI Official Symbol
RXRG
NCBI Official Synonym Symbols
RXRC; NR2B3
NCBI Protein Information
retinoic acid receptor RXR-gamma
UniProt Protein Name
Retinoic acid receptor RXR-gamma
Protein Family
UniProt Gene Name
RXRG
UniProt Synonym Gene Names
NR2B3
UniProt Entry Name
RXRG_HUMAN

NCBI Description

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

Uniprot Description

RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: nucleoplasm

Molecular Function: protein binding; zinc ion binding; retinoid-X receptor activity; steroid hormone receptor activity

Biological Process: retinoic acid receptor signaling pathway; neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; response to retinoic acid; regulation of myelination; heart development; steroid hormone mediated signaling; gene expression; transmembrane transport; protein homotetramerization; peripheral nervous system development

Research Articles on RXRG

Similar Products

Product Notes

The RXRG rxrg (Catalog #AAA9413542) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Retinoid X Receptor gamma Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Retinoid X Receptor gamma can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:500. Researchers should empirically determine the suitability of the RXRG rxrg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Retinoid X Receptor gamma, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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