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Rabbit anti-Human Reticulon 1 Polyclonal Antibody | anti-RTN1 antibody

Reticulon 1 Antibody

Gene Names
RTN1; NSP
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
Reticulon 1; Polyclonal Antibody; Reticulon 1 Antibody; Neuroendocrine specific protein; Neuroendocrine-specific protein; NSP; Reticulon-1; RTN 1; RTN1; RTN1_HUMAN; anti-RTN1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Reticulon 1 Antibody detects endogenous levels of total Reticulon 1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-RTN1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Post Translational Modifications
Isoforms RTN1-A and RTN1-B are phosphorylated.
Subunit Structure
Interacts with NDRG1.interacts with TMEM33.interacts with UGCG; regulates the ceramide glucosyltransferase activity of UGCG.
Tissue Specificity
Expressed in neural and neuroendocrine tissues and cell cultures derived therefrom. Expression of isoform RTN1-C is strongly correlated with neuronal differentiation.
Function
May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
23,576 Da
NCBI Official Full Name
Reticulon-1
NCBI Official Synonym Full Names
reticulon 1
NCBI Official Symbol
RTN1
NCBI Official Synonym Symbols
NSP
NCBI Protein Information
reticulon-1; neuroendocrine-specific protein
UniProt Protein Name
Reticulon-1
Protein Family
UniProt Gene Name
RTN1
UniProt Synonym Gene Names
NSP
UniProt Entry Name
RTN1_HUMAN

NCBI Description

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

Uniprot Description

RTN1: May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 14q23.1

Cellular Component: endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane

Molecular Function: protein binding

Biological Process: neuron differentiation

Research Articles on RTN1

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Product Notes

The RTN1 rtn1 (Catalog #AAA9629117) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Reticulon 1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Reticulon 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the RTN1 rtn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Reticulon 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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