Rabbit anti-Human REPS1 Polyclonal Antibody | anti-REPS1 antibody

REPS1 Antibody

Cat. Num. AAA7131558

• Gene Names: REPS1; RALBP1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: REPS1; Polyclonal Antibody; REPS1 Antibody; RALBP1; RALBP1 associated Eps domain containing 1; RalBP1-associated Eps domain-containing protein 1; RalBP1-interacting protein 1; anti-REPS1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; Rabbit IgG In Phosphate Buffered Saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% Sodium Azide and 50% Glycerol.

• Applicable Applications for anti-REPS1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:3000
• Immunogen: Synthesized peptide derived from C-terminal of human REPS1.
• Immunogen Species: Human
• Conjugate: Non-conjugated
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blot analysis of extracts from rat heart cells, using REPS1 antibody. )

Product Categories/Family for anti-REPS1 antibody

Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 190886437
• NCBI GeneID: 85021
• NCBI Accession #: NP_001122089.1
• NCBI GenBank Nucleotide #: NM_001128617.1
• UniProt Accession #: Q96D71; Q5JWJ5; Q5JWJ6; Q5JWJ7; Q8NDR7; Q8WU62; Q9BXY9; B7ZBZ8; B7ZBZ9; B7ZC00
• Molecular Weight: 86,662 Da
• NCBI Official Full Name: ralBP1-associated Eps domain-containing protein 1 isoform b
• NCBI Official Synonym Full Names: RALBP1 associated Eps domain containing 1
• NCBI Official Symbol: REPS1
• NCBI Official Synonym Symbols: RALBP1
• NCBI Protein Information: ralBP1-associated Eps domain-containing protein 1; ralBP1-interacting protein 1
• UniProt Protein Name: RalBP1-associated Eps domain-containing protein 1
• Protein Family: RalBP1-associated Eps domain-containing protein
• UniProt Gene Name: REPS1
• UniProt Entry Name: REPS1_HUMAN

NCBI Description

This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Uniprot Description

REPS1: a vesicle-associated protein that influences endocytosis through its ability to interact with Rab11FIP2 and RALBP1. An EGFR substrate that interacts with CRK and GRB2. May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2. Three alternatively spliced isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 6q24.1

Cellular Component: plasma membrane; coated pit

Molecular Function: protein binding; calcium ion binding; SH3 domain binding

Biological Process: receptor-mediated endocytosis