Western Blot (WB)
(Fig-1: Westren blot analysis of REG3A. Anti-REG3A antibody (11-4064) was used at 0.1 ug/ml on h Intestine lysate.)
Rabbit anti-Human REG3A Polyclonal Antibody | anti-REG3A antibody
Polyclonal Antibody to REG3A
Gene Names
REG3A; HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
Reactivity
Human
Applications
Western Blot
Purity
PurifiedProtein A Chromatography
Synonyms
REG3A; Polyclonal Antibody; Polyclonal Antibody to REG3A; HIP; PAP; PAP1; Hepatointestinal pancreatic protein; Human proislet peptide; Pancreatitis-associated protein 1; Reg III-alpha; Regenerating islet-derived protein III-alpha; Antibody to REG3A; Anti-REG3A Antibody; REG3A Antibody; anti-REG3A antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified
Protein A Chromatography
Protein A Chromatography
Form/Format
25 ug in 50 ul/100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Sequence Length
175
Applicable Applications for anti-REG3A antibody
Western Blot (WB)
Application Notes
WB: 0.1-0.5 ug/ml
Immunogen Information
A full length recombinant REG3A protein was used as the immunogen for this antibody.
Antigen
REG3A
Preparation and Storage
Store the antibody at 4 degree C, stable for 6 months.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
For long-term storage, store at -20 degree C.
Avoid repeated freeze and thaw cycles.
Western Blot (WB)
(Fig-1: Westren blot analysis of REG3A. Anti-REG3A antibody (11-4064) was used at 0.1 ug/ml on h Intestine lysate.)
Western Blot (WB)
(Fig-1: Westren blot analysis of REG3A. Anti-REG3A antibody (11-4064) was used at 0.1 ug/ml on h Intestine lysate.)
Related Product Information for anti-REG3A antibody
Regenerating islet-derived protein 3-alpha (REG3A), also known as hepatocarcinoma-intestine-pancreas/ pancreatitis-associated protein (HIP/PAP), is a secreted intestinal antimicrobial protein that functions in the control of the bacterial proliferation. It is normally expressed in pancreatic acinar and endocrine cells. REG3A is highly expressed in keratinocytes during psoriasis and wound repair and in imiquimod-induced psoriatic skin lesions. The expression of REG3A by keratinocytes is induced by interleukin-17 (IL-17) via activation of keratinocyte-encoded IL-17 receptor A (IL-17RA) and feeds back on keratinocytes to inhibit terminal differentiation and increase cell proliferation by binding to exostosin-like 3 (EXTL3). REG3A stimulates Beta-cell replication, by activating PI3K and Akt kinase and by increasing the levels of cyclin D1/CDK4. REG3A may be involved in cell recognition and adhesion, and also in the protection of cells from oxidative stress-induced apoptosis. REG3A mRNA expression is significantly down-regulated in gastric cancer mucosa, suggesting that the downregulation of REG3A occurs frequently in human gastric cancers and might be useful for a gastric cancer marker.
Product Categories/Family for anti-REG3A antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
19,395 Da
NCBI Official Full Name
Regenerating islet-derived protein 3-alpha
NCBI Official Synonym Full Names
regenerating family member 3 alpha
NCBI Official Symbol
REG3A
NCBI Official Synonym Symbols
HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
NCBI Protein Information
regenerating islet-derived protein 3-alpha
UniProt Protein Name
Regenerating islet-derived protein 3-alpha
Protein Family
UniProt Gene Name
REG3A
UniProt Synonym Gene Names
HIP; PAP; PAP1; REG-3-alpha; HIP/PAP; Reg III-alpha
NCBI Description
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
Uniprot Description
REG3A: Might be a stress protein involved in the control of bacterial proliferation.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: cytoplasm; extracellular space
Molecular Function: protein binding
Biological Process: cell proliferation; heterophilic cell adhesion; multicellular organismal development; negative regulation of keratinocyte differentiation
Research Articles on REG3A
Similar Products
Product Notes
The REG3A reg3a (Catalog #AAA668766) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to REG3A reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's REG3A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 0.1-0.5 ug/ml. Researchers should empirically determine the suitability of the REG3A reg3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "REG3A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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