Rabbit anti-Human RECK Polyclonal Antibody | anti-RECK antibody

RECK Rabbit Polyclonal

Cat. Num. AAA7603457

• Gene Names: RECK; ST15
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RECK; Polyclonal Antibody; RECK Rabbit Polyclonal; anti-RECK antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 225

• Applicable Applications for anti-RECK antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Reversion-inducing-cysteine-rich protein with kazal motifs
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(293T cells were subjected to SDS PAGE followed by western blot with MBS7603457 (RECK antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 939106617
• NCBI GeneID: 8434
• NCBI Accession #: NP_001303277.1
• NCBI GenBank Nucleotide #: NM_001316348.1
• Molecular Weight: 106,457 Da
• NCBI Official Full Name: reversion-inducing cysteine-rich protein with Kazal motifs isoform 5
• NCBI Official Synonym Full Names: reversion inducing cysteine rich protein with kazal motifs
• NCBI Official Symbol: RECK
• NCBI Official Synonym Symbols: ST15
• NCBI Protein Information: reversion-inducing cysteine-rich protein with Kazal motifs
• UniProt Protein Name: Reversion-inducing cysteine-rich protein with Kazal motifs
• Protein Family: Reversion-inducing cysteine-rich protein
• UniProt Gene Name: RECK
• UniProt Synonym Gene Names: ST15; hRECK
• UniProt Entry Name: RECK_HUMAN

NCBI Description

The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Uniprot Description

RECK: Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression. Interacts with MMP-9. Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.

Protein type: Membrane protein, GPI anchor; Tumor suppressor

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: membrane; plasma membrane

Molecular Function: endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: blood vessel maturation; embryo implantation; embryonic forelimb morphogenesis; extracellular matrix organization and biogenesis; negative regulation of cell migration