Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: RIPK2 knockout K562 cell lysate; Predicted MW: 61,46kd Observed MW: 44kd Primary Ab: 1ug/ml Rabbit Anti-Human RIPK2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Receptor Interacting Serine Threonine Kinase 2 (RIPK2) Polyclonal Antibody | anti-RIPK2 antibody
APC-Linked Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 2 (RIPK2)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: RIPK2 knockout K562 cell lysate; Predicted MW: 61,46kd Observed MW: 44kd Primary Ab: 1ug/ml Rabbit Anti-Human RIPK2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type K562 cell lysate; Lane 2: RIPK2 knockout K562 cell lysate; Predicted MW: 61,46kd Observed MW: 44kd Primary Ab: 1ug/ml Rabbit Anti-Human RIPK2 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
Uniprot Description
RIPK2: a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB.
Protein type: EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Chromosomal Location of Human Ortholog: 8q21.3
Cellular Component: cytoplasm; cytoskeleton; cytosol; protein complex; vesicle
Molecular Function: CARD domain binding; identical protein binding; LIM domain binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor binding; signal transducer activity
Biological Process: activation of MAPK activity; activation of NF-kappaB transcription factor; adaptive immune response; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; JNK cascade; MAPKKK cascade; negative regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein ubiquitination; signal transduction; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway
Research Articles on RIPK2
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Product Notes
The RIPK2 ripk2 (Catalog #AAA2059045) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The APC-Linked Polyclonal Antibody to Receptor Interacting Serine Threonine Kinase 2 (RIPK2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Receptor Interacting Serine Threonine Kinase 2 (RIPK2) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the RIPK2 ripk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Receptor Interacting Serine Threonine Kinase 2 (RIPK2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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