Rabbit RC3H1 Polyclonal Antibody | anti-RC3H1 antibody
RC3H1 Polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs (). Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner (). Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs (). In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity (). In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression (). Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation ().
Research Articles on RC3H1
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Product Notes
The RC3H1 rc3h1 (Catalog #AAA9135555) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The RC3H1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's RC3H1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:200 - 1:2000. Researchers should empirically determine the suitability of the RC3H1 rc3h1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: AAGSVEMMNV ESKGMRDQRL DLQRRAAETS DDDLIPFGDR PTVSRFGAIS RTSKTIYQGA GPMQAMAPQG APTKSINISD YSPYGTHGGW GASPYSPHQN IPSQGHFSER ERISMSEVAS HGKPLPSAER EQLRLELQQL NHQISQQTQL RGLEAVSNRL VLQREANTLA GQSQPPPPPP PKWPGMISSE QLSLELHQVE REIGKRTREL SMENQCSLDM KSKLNTSKQA ENGQPEPQNK VPAEDLTLTF SDVPN. It is sometimes possible for the material contained within the vial of "RC3H1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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