Western Blot (WB)
(RBBP8 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the RBBP8 antibody detected the RBBP8 protein (arrow).)
Rabbit anti-Human RBBP8 Polyclonal Antibody | anti-RBBP8 antibody
RBBP8 Antibody (C-term)
Western Blot (WB)
(RBBP8 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the RBBP8 antibody detected the RBBP8 protein (arrow).)
Western Blot (WB)
(RBBP8 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the RBBP8 antibody detected the RBBP8 protein (arrow).)
expressed nuclear protein. It is found among several proteins that
bind directly to retinoblastoma protein, which regulates cell
proliferation. This protein complexes with transcriptional
co-repressor CTBP. It is also associated with BRCA1 and is thought
to modulate the functions of BRCA1 in transcriptional regulation,
DNA repair, and/or cell cycle checkpoint control. It is suggested
that this gene may itself be a tumor suppressor acting in the same
pathway as BRCA1. Three transcript variants encoding two different
isoforms have been found for this gene. More transcript variants
exist, but their full-length natures have not been determined.
Thye, T., et al. Nat. Genet. 42(9):739-741(2010)
Notaridou, M., et al. Int. J. Cancer (2010) In press :
Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010)
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
CtIP: a transcription factor containing C2H2 zinc fingers. May modulate the functions ascribed to BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. Interacts with CTBP, with the C-terminal (BRCT) domains of BRCA1, and with the retinoblastoma protein. Abundantly expressed in brain and the immune system and associated with immune system malignancies. Ionizing radiation induces its hyperphosphorylation and dissociation from BRCA1 in an ATM-dependent manner.
Protein type: EC 3.1.-.-; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18q11.2
Cellular Component: nucleoplasm; transcriptional repressor complex; nucleolus; nucleus
Molecular Function: protein binding; single-stranded DNA specific endodeoxyribonuclease activity; damaged DNA binding
Biological Process: regulation of transcription from RNA polymerase II promoter; mitosis; meiotic cell cycle; cell division; blastocyst hatching; negative regulation of transcription from RNA polymerase II promoter; G2/M transition DNA damage checkpoint; DNA repair; DNA catabolic process, endonucleolytic; cell cycle checkpoint; double-strand break repair via homologous recombination; G1/S transition of mitotic cell cycle
Disease: Jawad Syndrome; Seckel Syndrome 2
Research Articles on RBBP8
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Product Notes
The RBBP8 rbbp8 (Catalog #AAA9208784) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 763-792. The RBBP8 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RBBP8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RBBP8 rbbp8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RBBP8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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