Rabbit anti-Human RAP2B Polyclonal Antibody | anti-RAP2B antibody

RAP2B Antibody

Cat. Num. AAA7046685

• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: RAP2B; Polyclonal Antibody; RAP2B Antibody; Ras-related protein Rap-2b; anti-RAP2B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 183

• Applicable Applications for anti-RAP2B antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human Ras-related protein Rap-2b protein (1-183AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue using MBS7046685 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7046685 at dilution 1:100)

Related Product Information for anti-RAP2B antibody

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.

NCBI and Uniprot Product Information

• NCBI GI #: 38201690
• NCBI GeneID: 5912
• NCBI Accession #: NP_002877.2
• NCBI GenBank Nucleotide #: NM_002886.3
• UniProt Accession #: P61225; P17964; Q96EG5; Q9CXG0
• Molecular Weight: 20,504 Da
• NCBI Official Full Name: ras-related protein Rap-2b
• NCBI Official Synonym Full Names: RAP2B, member of RAS oncogene family
• NCBI Official Symbol: RAP2B
• NCBI Protein Information: ras-related protein Rap-2b
• UniProt Protein Name: Ras-related protein Rap-2b
• Protein Family: Ras-related protein
• UniProt Gene Name: RAP2B
• UniProt Entry Name: RAP2B_HUMAN

NCBI Description

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008]

Uniprot Description

RAP2B: Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. Belongs to the small GTPase superfamily. Ras family.

Protein type: G protein, monomeric; G protein, monomeric, Ras; G protein

Chromosomal Location of Human Ortholog: 3q25.2

Cellular Component: cytosol; lipid raft; membrane; plasma membrane; recycling endosome membrane; tight junction

Molecular Function: GDP binding; GTP binding; protein binding

Biological Process: microvillus biogenesis; platelet activation; Rap protein signal transduction; signal transduction