Rabbit RAP1GAP Polyclonal Antibody | anti-RAP1GAP antibody

RAP1GAP Rabbit Polyclonal

Cat. Num. AAA7603343

• Gene Names: RAP1GAP; RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: RAP1GAP; Polyclonal Antibody; RAP1GAP Rabbit Polyclonal; anti-RAP1GAP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 663

• Applicable Applications for anti-RAP1GAP antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: RAP1 GTPase activating protein
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas tissue slide using MBS7603343 (RAP1GAP Antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7603343 (RAP1GAP antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 224809582
• NCBI GeneID: 5909
• NCBI Accession #: NP_002876.2
• NCBI GenBank Nucleotide #: NM_002885.2
• Molecular Weight: 80,645 Da
• NCBI Official Full Name: rap1 GTPase-activating protein 1 isoform c
• NCBI Official Synonym Full Names: RAP1 GTPase activating protein
• NCBI Official Symbol: RAP1GAP
• NCBI Official Synonym Symbols: RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII
• NCBI Protein Information: rap1 GTPase-activating protein 1
• UniProt Protein Name: Rap1 GTPase-activating protein 1
• Protein Family: Rap1 GTPase-activating protein
• UniProt Gene Name: RAP1GAP
• UniProt Synonym Gene Names: KIAA0474; RAP1GA1; Rap1GAP; Rap1GAP1
• UniProt Entry Name: RPGP1_HUMAN

NCBI Description

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]

Uniprot Description

RAP1GAP: a GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Protein type: Motility/polarity/chemotaxis; GAPs, Ras; GAPs

Chromosomal Location of Human Ortholog: 1p36.1-p35

Cellular Component: axon; cell soma; cytosol; dendrite; early endosome; Golgi membrane; membrane

Molecular Function: GTPase activator activity; GTPase activity; protein binding; protein homodimerization activity; Ras GTPase binding

Biological Process: negative regulation of neuron differentiation; positive regulation of GTPase activity; regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction