Rabbit Raftlin Polyclonal Antibody | anti-RFTN1 antibody

Raftlin Polyclonal Antibody

Cat. Num. AAA3006132

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Raftlin; Polyclonal Antibody; Raftlin Polyclonal Antibody; Cell migration-inducing gene 2 protein; Raft-linking protein; RFTN1; KIAA0084; ORF Names: MIG2; anti-RFTN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Raftlin polyclonal antibody detects endogenous levels of Raftlin protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 578

• Applicable Applications for anti-RFTN1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Synthetic peptide, corresponding to amino acids 475-520 of Human Raftlin.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Raftlin polyclonal antibody at 1:500 dilutionLane1:Hela cell lysateLane2:sp2/0 cell lysateLane3:H9C2 cell lysate)

Related Product Information for anti-RFTN1 antibody

Raftlin, also known as RFTN1 (raftlin, lipid raft linker 1), cell migration-inducing gene 2 protein, PIB10, PIG9 or MIG2, is a 578 amino acid cell membrane protein and lipid anchor that is essential for raft cell assembly and maintenance. A member of the raftlin family, Raftlin modulates B-cell antigen receptor-mediated signaling, TCR signals, and is involved in T cell-mediated immune responses. The gene encoding Raftlin maps to human chromosome 3, which houses over 1, 100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

NCBI and Uniprot Product Information

• NCBI GI #: 41872577
• NCBI Accession #: NP_055965.1
• NCBI GenBank Nucleotide #: NP_055965.1
• UniProt Accession #: Q14699
• Molecular Weight: ~ 63kDa
• NCBI Official Full Name: raftlin
• UniProt Protein Name: Raftlin
• Protein Family: Raftlin
• UniProt Gene Name: RFTN1
• UniProt Synonym Gene Names: KIAA0084
• UniProt Entry Name: RFTN1_HUMAN

Uniprot Description

RFTN1: May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor- mediated signaling. Belongs to the raftlin family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 3p24.3

Cellular Component: protein complex; cytoplasm; plasma membrane; endosome; lipid raft

Molecular Function: double-stranded RNA binding

Biological Process: protein transport into lipid raft; B cell receptor signaling pathway; response to exogenous dsRNA; T cell antigen processing and presentation; interleukin-17 production; dsRNA transport; toll-like receptor 3 signaling pathway; lipid raft formation; T cell receptor signaling pathway; growth