Rabbit anti-Human RAD54B Polyclonal Antibody | anti-RAD54B antibody

Anti-RAD54B Antibody, Rabbit Polyclonal

Cat. Num. AAA8101487

• Gene Names: RAD54B; RDH54
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: RAD54B; Polyclonal Antibody; Anti-RAD54B Antibody; Rabbit Polyclonal; RAD54B Antibody; Rabbit PAb; Antigen Affinity Purified; RAD54 homolog B (S. cerevisiae); Anti-RDH54 Antibody; anti-RAD54B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human RAD54B
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-RAD54B antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the N-terminus of the Human RAD54B
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human RAD54B, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human RAD54B in human testis with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-RAD54B antibody

RAD54 homolog B is a central motor protein of homologous recombination (HR), which plays an important role in the development and evolution of human cancer. Recent studies have indicated that RAD54B is aberrantly expressed in a variety of cancers and exhibits numerous biological functions, including participating in the repair of DNA double-strand breaks. The human RAD54B protein is a paralog of the RAD54 protein, which plays important roles in homologous recombination. RAD54B contains an N-terminal region outside the SWI2/SNF2 domain that shares less conservation with the corresponding region in RAD54.

NCBI and Uniprot Product Information

• NCBI GI #: 327532753
• NCBI GeneID: 25788
• NCBI Accession #: NP_001192192.1
• NCBI GenBank Nucleotide #: NM_001205263.1
• UniProt Accession #: Q9Y620; F6WBS8
• Molecular Weight: 102,967 Da
• NCBI Official Full Name: DNA repair and recombination protein RAD54B isoform 3
• NCBI Official Synonym Full Names: RAD54 homolog B (S. cerevisiae)
• NCBI Official Symbol: RAD54B
• NCBI Official Synonym Symbols: RDH54
• NCBI Protein Information: DNA repair and recombination protein RAD54B
• UniProt Protein Name: DNA repair and recombination protein RAD54B
• Protein Family: DNA repair and recombination protein
• UniProt Gene Name: RAD54B
• UniProt Entry Name: RA54B_HUMAN

NCBI Description

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]

Uniprot Description

RAD54B: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group. Belongs to the SNF2/RAD54 helicase family.

Protein type: EC 3.6.1.-; EC 3.6.4.-; Helicase; DNA repair, damage

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nucleus

Molecular Function: DNA helicase activity; DNA binding; DNA translocase activity; RNA helicase activity; ATP binding

Biological Process: mitotic recombination; meiotic recombination; DNA duplex unwinding; double-strand break repair via homologous recombination

Disease: Lymphoma, Non-hodgkin, Familial