Rabbit RAB7A Polyclonal Antibody | anti-RAB7A antibody

RAB7A Rabbit pAb

Cat. Num. AAA8548750

• Gene Names: RAB7A; RAB7; CMT2B; PRO2706
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified
• Synonyms: RAB7A; Polyclonal Antibody; RAB7A Rabbit pAb; RAB7; PRO2706; anti-RAB7A antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
• Sequence Length: 207

• Applicable Applications for anti-RAB7A antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RAB7A (NP_004628.4).
• Cellular Localization: Cytoplasmic Vesicle, Endosome, Lipid Droplet, Lysosome, Membrane
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-RAB7A antibody

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).

NCBI and Uniprot Product Information

• NCBI GI #: 1709999
• NCBI GeneID: 7879
• UniProt Accession #: P51149
• Molecular Weight: 23kDa
• NCBI Official Full Name: Ras-related protein Rab-7a
• NCBI Official Synonym Full Names: RAB7A, member RAS oncogene family
• NCBI Official Symbol: RAB7A
• NCBI Official Synonym Symbols: RAB7; CMT2B; PRO2706
• NCBI Protein Information: ras-related protein Rab-7a
• UniProt Protein Name: Ras-related protein Rab-7a
• Protein Family: Ras-related protein
• UniProt Gene Name: RAB7A
• UniProt Synonym Gene Names: RAB7
• UniProt Entry Name: RAB7A_HUMAN

NCBI Description

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]

Uniprot Description

Rab7: a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy.

Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: Golgi apparatus; phagocytic vesicle membrane; intracellular membrane-bound organelle; lysosome; retromer complex; lysosomal membrane; late endosome; vacuolar membrane; pre-autophagosomal structure membrane; melanosome; phagocytic vesicle

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; Rac GTPase binding

Biological Process: protein transport; protein targeting to lysosome; early endosome to late endosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; endosome to lysosome transport; endocytosis; protein to membrane docking; Rab protein signal transduction; retrograde transport, endosome to Golgi; epidermal growth factor ligand processing; bone resorption

Disease: Charcot-marie-tooth Disease, Axonal, Type 2b