Reactivity Chart
Goat Rab27a Polyclonal Antibody | anti-Rab27a antibody
Rab27a Polyclonal Antibody
Immunofluorescence: 1:50-1:200
Reactivity Chart
Reactivity Chart
Testing Data
Testing Data
Goat polyclonal antibody to mouse Rab27a. Rab27a belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and involved in lysosome-related vesicle transport and small GTPase mediated signal transduction.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Ref.15
Subunit structure: Binds SYTL1, SLAC2B, MYRIP, SYTL3, SYTL4 and SYTL5. Interacts with RPH3A and RPH3A
By similarity. Binds MLPH and SYTL2. Interacts with UNC13D. Ref.10 Ref.12 Ref.14 Ref.15
Subcellular location: Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. Ref.11 Ref.12 Ref.13 Ref.14
Tissue specificity: Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. Ref.12
Involvement in disease: Griscelli syndrome 2 (GS2) [MIM:607624]: Rare autosomal recessive disorder that results in pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes. GS2 patients also develop an uncontrolled T-lymphocyte and macrophage activation syndrome, known as hemophagocytic syndrome, leading to death in the absence of bone marrow transplantation. Neurological impairment is present in some patients, likely as a result of hemophagocytic syndrome.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.17 Ref.20 Ref.21
Sequence similarities: Belongs to the small GTPase superfamily. Rab family.
Research Articles on Rab27a
Similar Products
Product Notes
The Rab27a rab27a (Catalog #AAA448038) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Rab27a Polyclonal Antibody reacts with Human, mouse, rat, bovine, canine, chickevian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep, simian and may cross-react with other species as described in the data sheet. AAA Biotech's Rab27a can be used in a range of immunoassay formats including, but not limited to, Immunofluorescence (IF), Western Blot (WB). Western Blot: 1:250-1:1,000 Immunofluorescence: 1:50-1:200. Researchers should empirically determine the suitability of the Rab27a rab27a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Rab27a, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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