Western Blot (WB)
(RAB11A Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RAB11A antibody detected the RAB11A protein (arrow).)
Rabbit RAB11A Polyclonal Antibody | anti-RAB11A antibody
RAB11A Antibody (Center)
Western Blot (WB)
(RAB11A Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RAB11A antibody detected the RAB11A protein (arrow).)
Western Blot (WB)
(RAB11A Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the RAB11A antibody detected the RAB11A protein (arrow).)
GTPase superfamily, Rab family. It is associated with both
constitutive and regulated secretory pathways, and may be involved
in protein transport.
Cayouette, S., et al. Biochim. Biophys. Acta 1803(7):805-812(2010)
Reid, H.M., et al. J. Biol. Chem. 285(24):18709-18726(2010)
Bruce, E.A., et al. J. Virol. 84(12):5848-5859(2010)
Knodler, A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(14):6346-6351(2010)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Uniprot Description
RAB11A: Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. Interacts with RIP11 and STXBP6. Interacts with SGSM1, SGSM2 and SGSM3. Interacts with EXOC6 in a GTP- dependent manner. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 (via its C-terminus) and RAB11FIP4. Interacts with EVI5; EVI5 and RAB11FIP3 may be mutually exclusive and compete for binding RAB11A. Interacts with SPE39//C14orf133. Interacts with MYO5B. Found in a complex with MYO5B and CFTR. Interacts with NPC1L1. Interacts (GDP-bound form) with ZFYVE27. Interacts with BIRC6/bruce. Belongs to the small GTPase superfamily. Rab family.
Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Rab; G protein; G protein, monomeric
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component: Golgi apparatus; spindle pole; protein complex; cytoplasmic vesicle membrane; mitochondrion; recycling endosome membrane; trans-Golgi network; phagocytic vesicle; cytosol; kinetochore microtubule; multivesicular body; phagocytic vesicle membrane; recycling endosome; transport vesicle; perinuclear region of cytoplasm; axon; plasma membrane; cytoplasmic vesicle; vesicle; cleavage furrow
Molecular Function: GTPase activity; protein binding; GDP binding; syntaxin binding; GTP binding; microtubule binding; myosin V binding
Biological Process: regulation of long-term neuronal synaptic plasticity; establishment of vesicle localization; exocytosis; metabolic process; organelle organization and biogenesis; water transport; positive regulation of axon extension; cytokinesis; mitotic metaphase plate congression; melanosome transport; regulation of protein transport; vesicle-mediated transport; intracellular protein transport; astral microtubule organization and biogenesis; renal water homeostasis; plasma membrane to endosome transport; Rab protein signal transduction; transmembrane transport; neurite development
Research Articles on RAB11A
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Product Notes
The RAB11A rab11a (Catalog #AAA9204669) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 88-116. The RAB11A Antibody (Center) reacts with Human (Predicted Reactivity: Bovine, Chicken, Mouse, Pig, Rabbit, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's RAB11A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the RAB11A rab11a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAB11A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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