Rabbit PZP Polyclonal Antibody | anti-PZP antibody

Anti PZP polyclonal antibody

Cat. Num. AAA1560289

• Gene Names: PZP; CPAMD6
• Reactivity: Human; Other species were not tested
• Applications: Immunohistochemistry, Immunocytochemistry
• Purity: Antigen affinity purification
• Synonyms: PZP; Polyclonal Antibody; Anti PZP polyclonal antibody; Pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6; CPAMD6; anti-PZP antibody

• Host: Rabbit
• Reactivity: Human; Other species were not tested
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Form/Format: Liquid. Supplied as solution form in PBS, pH7.4, containing 0.05% proclin300, 50% glycerol.
• Concentration: 1.44mg/ml (varies by lot)

• Applicable Applications for anti-PZP antibody: Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Application Notes: ICC: 1:50~200; IHC: 1:50~100
• Immunogen: Recombinant protein of human PZP (Asn341-Ser690)
• Conjugation: Unconjugated
• Dry Ice Shipment: Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
• Preparation and Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 degree C for frequent use. Store at -20 to -80 degree C for twelve months from the date of receipt.

Immunofluorescence (IF)

Related Product Information for anti-PZP antibody

Pregnancy Zone protein is a 1, 482 amino acid secreted protein that belongs to the protease inhibitor I39 family and exists as multiple alternatively spliced isoforms. Expressed predominately in plasma and in late-pregnancy sera, Pregnancy Zone protein functions as a disulfide-linked homotetramer that is able to trap and inhibit proteinases, thus playing a role in the regulation of protein splitting and small peptide formation. The gene encoding Pregnancy Zone protein maps to human chromosome 12, which encodes over 1, 100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.

Product Categories/Family for anti-PZP antibody

Primary antibody

References

PMID: 1692292; PMID: 1989698; PMID: 16959974

NCBI and Uniprot Product Information

• NCBI GI #: 281185515
• NCBI GeneID: 5858
• UniProt Accession #: P20742; Q15273; Q2NKL2; Q7M4N7; A6ND27
• Molecular Weight: 164kDa
• NCBI Official Full Name: Pregnancy zone protein
• NCBI Official Synonym Full Names: pregnancy-zone protein
• NCBI Official Symbol: PZP
• NCBI Official Synonym Symbols: CPAMD6
• NCBI Protein Information: pregnancy zone protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6
• UniProt Protein Name: Pregnancy zone protein
• Protein Family: Pregnancy zone protein
• UniProt Gene Name: PZP
• UniProt Synonym Gene Names: CPAMD6
• UniProt Entry Name: PZP_HUMAN

Uniprot Description

PZP: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12p13-p12.2

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity

Biological Process: female pregnancy