Western Blot (WB)
(PYDC1 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PYDC1 antibody detected the PYDC1 protein (arrow).)
Rabbit anti-Human PYDC1 Polyclonal Antibody | anti-PYDC1 antibody
PYDC1, ID (PYDC1, ASC2, ASCI, POP1, PYC1, Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1) (AP)
Gene Names
PYDC1; ASC2; POP1; PYC1
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Purified by Protein A Affinity Chromatography.
Synonyms
PYDC1; Polyclonal Antibody; ID (PYDC1; ASC2; ASCI; POP1; PYC1; Pyrin domain-containing protein 1; PAAD-only protein 1; Pyrin-only protein 1) (AP); Pyrin-only protein 1; anti-PYDC1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Purified by Protein A Affinity Chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Applicable Applications for anti-PYDC1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.
ELISA: 1:1,000
Applications are based on unconjugated antibody.
Immunogen
PYDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-42 amino acids from the Central region of human PYDC1.
Conjugate
AP
Note
Preservative Free
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Western Blot (WB)
(PYDC1 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PYDC1 antibody detected the PYDC1 protein (arrow).)
Western Blot (WB)
(PYDC1 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PYDC1 antibody detected the PYDC1 protein (arrow).)
Related Product Information for anti-PYDC1 antibody
PYDC1 associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Product Categories/Family for anti-PYDC1 antibody
References
Son, Y.L., et al. Biochem. J. 410(2):319-330(2008). Natarajan, A., et al. J. Biol. Chem. 281(42):31863-31875(2006). Espejo, F., et al. Biochem. Biophys. Res. Commun. 340(3):860-864(2006). Stehlik, C., et al. Biochem. J. 373 (PT 1), 101-113 (2003): Pawlowski, K., et al. Trends Biochem. Sci. 26(2):85-87(2001).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
10,107 Da
NCBI Official Full Name
pyrin domain-containing protein 1
NCBI Official Synonym Full Names
PYD (pyrin domain) containing 1
NCBI Official Symbol
PYDC1
NCBI Official Synonym Symbols
ASC2; POP1; PYC1
NCBI Protein Information
pyrin domain-containing protein 1; PAAD-only protein 1; pyrin-only protein 1; pyrin domain containing 1; pyrin-domain containing protein 1
UniProt Protein Name
Pyrin domain-containing protein 1
Protein Family
UniProt Gene Name
PYDC1
UniProt Synonym Gene Names
cPOP1
Uniprot Description
PYDC1: Associates with apoptosis-associated specklike protein containing a CARD domain (ASC) and modulates its ability to collaborate with pyrin and cryopyrin in NF-kappa-B and pro- caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cytosol; IkappaB kinase complex; nucleus
Molecular Function: protein binding
Biological Process: inhibition of NF-kappaB transcription factor; innate immune response; negative regulation of interleukin-1 beta secretion; negative regulation of protein kinase activity; positive regulation of interleukin-1 beta secretion; tumor necrosis factor-mediated signaling pathway
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Product Notes
The PYDC1 pydc1 (Catalog #AAA6339349) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PYDC1, ID (PYDC1, ASC2, ASCI, POP1, PYC1, Pyrin domain-containing protein 1, PAAD-only protein 1, Pyrin-only protein 1) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PYDC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:100-500 ELISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PYDC1 pydc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PYDC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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