Western Blot (WB)
(Western Blot analysis of PTPRR expression in transfected 293T cell line by PTPRR polyclonal antibody. Lane 1: PTPRR transfected lysate (73.9kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human PTPRR Polyclonal Antibody | anti-PTPRR antibody
PTPRR (Receptor-type Tyrosine-protein Phosphatase R, R-PTP-R, Ch-1PTPase, NC-PTPCOM1, Protein-tyrosine Phosphatase PCPTP1, ECPTP, PTPRQ, DKFZp781C1038, FLJ34328, MGC131968, MGC148170) (AP)
Western Blot (WB)
(Western Blot analysis of PTPRR expression in transfected 293T cell line by PTPRR polyclonal antibody. Lane 1: PTPRR transfected lysate (73.9kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of PTPRR expression in transfected 293T cell line by PTPRR polyclonal antibody. Lane 1: PTPRR transfected lysate (73.9kD). Lane 2: Non-transfected lysate.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between PTPRR and MAPK1 HeLa cells were stained with PTPRR rabbit purified polyclonal 1:1200 and MAPK1 mouse monoclonal antibody 1:50. Signals were detected by 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between PTPRR and MAPK1 HeLa cells were stained with PTPRR rabbit purified polyclonal 1:1200 and MAPK1 mouse monoclonal antibody 1:50. Signals were detected by 30 Detection Kit 613 (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]
Uniprot Description
PTP-SL: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor protein phosphatase, tyrosine; EC 3.1.3.48; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q15
Cellular Component: extracellular space; perinuclear region of cytoplasm; integral to membrane; plasma membrane
Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding
Biological Process: in utero embryonic development; protein amino acid dephosphorylation
Research Articles on PTPRR
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Product Notes
The PTPRR ptprr (Catalog #AAA6391462) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPRR (Receptor-type Tyrosine-protein Phosphatase R, R-PTP-R, Ch-1PTPase, NC-PTPCOM1, Protein-tyrosine Phosphatase PCPTP1, ECPTP, PTPRQ, DKFZp781C1038, FLJ34328, MGC131968, MGC148170) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTPRR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PTPRR ptprr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPRR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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