Rabbit anti-Human PTPRN2 Polyclonal Antibody | anti-PTPRN2 antibody

PTPRN2 Antibody (N-term)

Cat. Num. AAA9207078

• Gene Names: PTPRN2; IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: PTPRN2; Polyclonal Antibody; PTPRN2 Antibody (N-term); Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin; KIAA0387; anti-PTPRN2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This PTPRN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the N-terminal region of human PTPRN2.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Positions: 161-189
• Sequence Length: 998

• Applicable Applications for anti-PTPRN2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(PTPRN2 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PTPRN2 antibody detected the PTPRN2 protein (arrow).)

Related Product Information for anti-PTPRN2 antibody

The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP possesses an extracellular
region, a single transmembrane region, and a single intracellular
catalytic domain, and thus represents a receptor-type PTP. The
catalytic domain of this PTP is most closely related to
PTPRN/IA-2beta. This PTP and PTPRN are both found to be major
autoantigens associated with insulin-dependent diabetes mellitus.
Three alternatively spliced transcript variants of this gene, which
encode distinct proteins, have been reported.

Product Categories/Family for anti-PTPRN2 antibody

Immunology; Signal Transduction

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

NCBI and Uniprot Product Information

• NCBI GI #: 194097440
• NCBI GeneID: 5799
• NCBI Accession #: NP_002838.2; NP_570857.2; NP_570858.2
• NCBI GenBank Nucleotide #: NM_002847.4
• UniProt Accession #: Q92932; Q8N4I5; Q92662; Q9Y4F8; Q9Y4I6; E9PC57
• Molecular Weight: 111271
• NCBI Official Full Name: receptor-type tyrosine-protein phosphatase N2 isoform 1
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type, N polypeptide 2
• NCBI Official Symbol: PTPRN2
• NCBI Official Synonym Symbols: IAR; ICAAR; PTPRP; IA-2beta; R-PTP-N2
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase N2
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase N2
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRN2
• UniProt Synonym Gene Names: KIAA0387; R-PTP-N2; IAR; ICAAR
• UniProt Entry Name: PTPR2_HUMAN

NCBI Description

This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

PTPRN2: Implicated in development of nervous system and pancreatic endocrine cells. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q36

Cellular Component: integral to plasma membrane; endoplasmic reticulum lumen; terminal button; receptor complex; secretory granule

Molecular Function: transmembrane receptor protein tyrosine phosphatase activity

Biological Process: protein amino acid dephosphorylation