Western Blot (WB)
(Western Blot analysis of Jurkat cell line lysates (35ug/lane) usingMBS645228. This demonstrates that MBS645228 detected the PTPRN protein (arrow).)
Rabbit anti-Human PTPRN Polyclonal Antibody | anti-PTPRN antibody
PTPRN, ID (PTPRN, ICA3, ICA512, Receptor-type tyrosine-protein phosphatase-like N, Islet cell antigen 512, Islet cell autoantigen 3, PTP IA-2) (APC)
Western Blot (WB)
(Western Blot analysis of Jurkat cell line lysates (35ug/lane) usingMBS645228. This demonstrates that MBS645228 detected the PTPRN protein (arrow).)
Western Blot (WB)
(Western Blot analysis of Jurkat cell line lysates (35ug/lane) usingMBS645228. This demonstrates that MBS645228 detected the PTPRN protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]
Uniprot Description
PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2q35-q36.1
Cellular Component: integral to membrane
Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity
Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus
Research Articles on PTPRN
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Product Notes
The PTPRN ptprn (Catalog #AAA6339086) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTPRN, ID (PTPRN, ICA3, ICA512, Receptor-type tyrosine-protein phosphatase-like N, Islet cell antigen 512, Islet cell autoantigen 3, PTP IA-2) (APC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTPRN can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PTPRN ptprn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTPRN, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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